Anti-FANCA Antibody (CAB9529)
- SKU:
- CAB9529
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-FANCA Antibody |
抗体コード: | CAB9529 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human FANCA |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | HeLa, HT-29, 293T |
免疫原: | A synthesized peptide derived from human FANCA |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 2175 |
Uniprot: | O15360 |
セルラーロケーション: | |
計算された分子量: | 163Da |
観察された分子量: | 163KDa |
同義語: | FA, FA-H, FA1, FAA, FACA, FAH, FANCH |
バックグラウンド: | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. [provided by RefSeq, Jul 2008] |
UniProt Protein Function: | FANCA: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Defects in FANCA are a cause of Fanconi anemia (FA). FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA repair, damage Chromosomal Location of Human Ortholog: 16q24.3 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding Biological Process: DNA repair; protein complex assembly Disease: Fanconi Anemia, Complementation Group A; Tracheoesophageal Fistula With Or Without Esophageal Atresia |
NCBI Summary: | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. [provided by RefSeq, Jul 2008] |
UniProt Code: | O15360 |
NCBI GenInfo Identifier: | 147744560 |
NCBI Gene ID: | 2175 |
NCBI Accession: | O15360.2 |
UniProt Secondary Accession: | O15360,O75266, Q6PL10, Q92497, Q96H18, Q9UEA5, Q9UEL8 Q9UEL9, Q9UPK3, A5D923, B4DRI7, H3BSR5, |
UniProt Related Accession: | O15360 |
Molecular Weight: | 159,083 Da |
NCBI Full Name: | Fanconi anemia group A protein |
NCBI Synonym Full Names: | Fanconi anemia complementation group A |
NCBI Official Symbol: | FANCA |
NCBI Official Synonym Symbols: | FA; FA1; FAA; FAH; FA-H; FACA; FANCH |
NCBI Protein Information: | Fanconi anemia group A protein |
UniProt Protein Name: | Fanconi anemia group A protein |
Protein Family: | Fanconi anemia group A protein |
UniProt Gene Name: | FANCA |
UniProt Entry Name: | FANCA_HUMAN |
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