Anti-FABP4 Antibody (CAB11481)
- SKU:
- CAB11481
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-FABP4 Antibody |
抗体コード: | CAB11481 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human FABP4 |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse heart, Mouse thymus, Rat heart, Rat thymus |
免疫原: | A synthesized peptide derived from human FABP4 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 2167 |
Uniprot: | P15090 |
セルラーロケーション: | |
計算された分子量: | 15kDa |
観察された分子量: | 15KDa |
同義語: | A-FABP, AFABP, ALBP, HEL-S-104, aP2 |
バックグラウンド: | FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008] |
UniProt Protein Function: | FABP4: a lipid transport protein that is the predominant fatty acid binding protein found in adipocytes. Also expressed in macrophages. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. Homodimer. Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Interacts with PPARG. Monomer. FABP4 knockout mice fed a high-fat and high-calorie diet become obese but develop neither insulin resistance nor diabetes, suggesting that this protein might be a link between obesity and insulin resistance and diabetes. Mice deficient in both FABP4 and ApoE show protection against atherosclerosis when compared with mice deficient only in ApoE. Mice carrying a FABP4 genetic variant exhibit both reduced FABP4 expression and a reduced potential for developing type 2 diabetes and coronary heart disease. A related study in humans indicated a similar pattern, suggesting that FABP4 may be a potential therapeutic target in the treatment of these disorders. Belongs to the calycin superfamily,fatty-acid binding protein (FABP) family. |
UniProt Protein Details: | Protein type:Lipid-binding Chromosomal Location of Human Ortholog: 8q21 Cellular Component: cytoplasm; lipid particle; nucleus Molecular Function:transporter activity; fatty acid binding Biological Process: cholesterol homeostasis; transport; white fat cell differentiation; triacylglycerol catabolic process; brown fat cell differentiation; negative regulation of protein kinase activity; cytokine production; negative regulation of transcription, DNA-dependent; positive regulation of inflammatory response |
NCBI Summary: | FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008] |
UniProt Code: | P15090 |
NCBI GenInfo Identifier: | 119781 |
NCBI Gene ID: | 2167 |
NCBI Accession: | P15090.3 |
UniProt Secondary Accession: | P15090,Q6IBA1, |
UniProt Related Accession: | P15090 |
Molecular Weight: | 132 |
NCBI Full Name: | Fatty acid-binding protein, adipocyte |
NCBI Synonym Full Names: | fatty acid binding protein 4, adipocyte |
NCBI Official Symbol: | FABP4 |
NCBI Official Synonym Symbols: | aP2; ALBP; AFABP; A-FABP; HEL-S-104 |
NCBI Protein Information: | fatty acid-binding protein, adipocyte; fatty acid-binding protein 4; adipocyte lipid-binding protein; epididymis secretory protein Li 104; adipocyte-type fatty acid-binding protein |
UniProt Protein Name: | Fatty acid-binding protein, adipocyte |
UniProt Synonym Protein Names: | Adipocyte lipid-binding protein; ALBP; Adipocyte-type fatty acid-binding protein; A-FABP; AFABP; Fatty acid-binding protein 4 |
Protein Family: | Fatty acid-binding protein |
UniProt Gene Name: | FABP4 |
UniProt Entry Name: | FABP4_HUMAN |