Anti-EPRS Antibody (CAB15245)
- SKU:
- CAB15245
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-EPRS Antibody |
抗体コード: | CAB15245 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 900-1000 of human EPRS (NP_004437.2). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:1000 IHC 1:50 - 1:100 |
反応性: | Human |
ポジティブサンプル: | 293T, HeLa |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 900-1000 of human EPRS (NP_004437.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | EAKV LFDK VASQ GEVV RKLK TEKA PKDQ VDIA VQEL LQLK AQYK SLIG VEYK PVSA TGAE DKDK KKKE KENK SEKQ NKPQ KQND GQRK DPSK NQGG GLSS S |
遺伝子ID: | 2058 |
Uniprot: | P07814 |
セルラーロケーション: | Cytoplasm |
計算された分子量: | 170kDa |
観察された分子量: | 190kDa |
同義語: | EPRS, EARS, GLUPRORS, PARS, PIG32, QARS, QPRS |
バックグラウンド: | Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. |
UniProt Protein Function: | EPRS: Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well as three auxiliary proteins, p18, p48 and p43. Interacts with DUS2L. |
UniProt Protein Details: | Protein type:Translation; EC 6.1.1.17; Ligase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 6.1.1.15 Chromosomal Location of Human Ortholog: 1q41 Cellular Component: cytoplasm; cytosol; membrane; ribonucleoprotein complex Molecular Function:glutamate-tRNA ligase activity; GTPase binding; proline-tRNA ligase activity; protein binding Biological Process: negative regulation of translation; prolyl-tRNA aminoacylation; protein complex assembly; tRNA aminoacylation for protein translation |
NCBI Summary: | Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | P07814 |
NCBI GenInfo Identifier: | 288558855 |
NCBI Gene ID: | 2058 |
NCBI Accession: | P07814.5 |
UniProt Secondary Accession: | P07814,Q05BP6, Q05DF8, Q5DSM1, Q5H9S5, Q6PD57, Q86X73 A0AVA9, B9EGH3, |
UniProt Related Accession: | P07814 |
Molecular Weight: | 170,591 Da |
NCBI Full Name: | Bifunctional glutamate/proline--tRNA ligase |
NCBI Synonym Full Names: | glutamyl-prolyl-tRNA synthetase |
NCBI Official Symbol: | EPRS |
NCBI Official Synonym Symbols: | EARS; PARS; QARS; QPRS; PIG32; GLUPRORS |
NCBI Protein Information: | bifunctional glutamate/proline--tRNA ligase |
UniProt Protein Name: | Bifunctional glutamate/proline--tRNA ligase |
UniProt Synonym Protein Names: | Bifunctional aminoacyl-tRNA synthetase; Cell proliferation-inducing gene 32 protein; Glutamatyl-prolyl-tRNA synthetaseIncluding the following 2 domains:Glutamate--tRNA ligase (EC:6.1.1.17)Alternative name(s):Glutamyl-tRNA synthetase; GluRS |
UniProt Gene Name: | EPRS |
UniProt Entry Name: | SYEP_HUMAN |
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