Anti-ELAC2 Antibody (CAB7128)
- SKU:
- CAB7128
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-ELAC2 Antibody |
抗体コード: | CAB7128 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human ELAC2 (NP_776065.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | MCF7, NCI-H460 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human ELAC2 (NP_776065.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MWAL CSLL RSAA GRTM SQGR TISQ APAR RERP RKDP LRHL RTRE KRGP SGCS GGPN TVYL QVVA AGSR DSGA ALYV FSEF NRYL FNCG EGVQ RLMQ EHKL KVAR LDNI FLTR MHWS NVGG LSGM ILTL KETG LPKC VLSG PPQL EKYL EAIK IFSG PLKG IELA VRPH SAPE YEDE TMTV YQIP IHSE QRRG KHQP WQSP ERPL SRLS PERS SDSE SNEN EPHL PHGV SQRR GVRD SSLV VAFI CKLH LKRG NFLV LKAK EMGL PVGT AA |
遺伝子ID: | 60528 |
Uniprot: | Q9BQ52 |
セルラーロケーション: | Mitochondrion, Nucleus |
計算された分子量: | 50kDa/56kDa/87kDa/92kDa |
観察された分子量: | 105kDa |
同義語: | ELAC2, COXPD17, ELC2, HPC2 |
バックグラウンド: | The protein encoded by this gene has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | ELAC2: a zinc phosphodiesterase. Putative prostate cancer susceptibility protein. |
UniProt Protein Details: | Protein type:Ribonuclease; Oncoprotein; RNA processing; EC 3.1.26.11; Phosphodiesterase Chromosomal Location of Human Ortholog: 17p11.2 Cellular Component: nucleoplasm; mitochondrion; nucleus Molecular Function:metal ion binding; endonuclease activity Disease: Prostate Cancer, Hereditary, 2; Combined Oxidative Phosphorylation Deficiency 17 |
NCBI Summary: | The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
UniProt Code: | Q9BQ52 |
NCBI GenInfo Identifier: | 41017788 |
NCBI Gene ID: | 60528 |
NCBI Accession: | Q9BQ52.2 |
UniProt Secondary Accession: | Q9BQ52,Q6IA94, Q9HAS8, Q9HAS9, Q9NVT1, B4DPL9, |
UniProt Related Accession: | Q9BQ52 |
Molecular Weight: | 826 |
NCBI Full Name: | Zinc phosphodiesterase ELAC protein 2 |
NCBI Synonym Full Names: | elaC ribonuclease Z 2 |
NCBI Official Symbol: | ELAC2 |
NCBI Official Synonym Symbols: | ELC2; HPC2; COXPD17 |
NCBI Protein Information: | zinc phosphodiesterase ELAC protein 2; RNase Z 2; tRNase Z 2; elaC homolog 2; ribonuclease Z 2; tRNase Z (long form); tRNA 3 endonuclease 2; elaC homolog protein 2; heredity prostate cancer protein 2; putative prostate cancer susceptibility protein HPC2/ELAC2 |
UniProt Protein Name: | Zinc phosphodiesterase ELAC protein 2 |
UniProt Synonym Protein Names: | ElaC homolog protein 2; Heredity prostate cancer protein 2; Ribonuclease Z 2; RNase Z 2; tRNA 3 endonuclease 2; tRNase Z 2 |
Protein Family: | Zinc phosphodiesterase ELAC protein |
UniProt Gene Name: | ELAC2 |
UniProt Entry Name: | RNZ2_HUMAN |
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