Anti-EIF2B5 Antibody (CAB10263)
- SKU:
- CAB10263
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
抗体名: | Anti-EIF2B5 Antibody |
抗体コード: | CAB10263 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF IP |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 442-721 of human EIF2B5 (NP_003898.2). |
申し込み: | WB IHC IF IP |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-87MG, A-549, HL-60, HT-1080, LO2, Mouse brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 442-721 of human EIF2B5 (NP_003898.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | TLPE GSVI SLHP PDAE EDED DGEF SDDS GADQ EKDK VKMK GYNP AEVG AAGK GYLW KAAG MNME EEEE LQQN LWGL KINM EEES ESES EQSM DSEE PDSR GGSP QMDD IKVF QNEV LGTL QRGK EENI SCDN LVLE INSL KYAY NISL KEVM QVLS HVVL EFPL QQMD SPLD SSRY CALL LPLL KAWS PVFR NYIK RAAD HLEA LAAI EDFF LEHE ALGI SMAK VLMA FYQL EILA EETI LSWF SQRD TTDK GQQL RKNQ QLQR FIQW LKEA EEES SEDD |
遺伝子ID: | 8893 |
Uniprot: | Q13144 |
セルラーロケーション: | |
計算された分子量: | 80kDa |
観察された分子量: | 85kDa |
同義語: | EIF2B5, CACH, CLE, EIF-2B, EIF2Bepsilon, LVWM |
バックグラウンド: | This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. |
UniProt Protein Function: | eIF2B-epsilon: eukaryotic translation initiation factor 2B, subunit 5. A translational regulatory protein that functions in the early steps of protein synthesis by catalyzing the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Mutation in EIF2B5 causes childhood ataxia with central nervous system hypomyelination/ vanishing white matter leukodystrophy. |
UniProt Protein Details: | Protein type:Translation; Translation initiation Chromosomal Location of Human Ortholog: 3q27.1 Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 2B complex; nucleus Molecular Function:guanyl-nucleotide exchange factor activity; protein binding; translation initiation factor activity; translation initiation factor binding Biological Process: astrocyte development; astrocyte differentiation; myelination; negative regulation of translation initiation in response to stress; oligodendrocyte development; ovarian follicle development; positive regulation of translational initiation; response to glucose stimulus; response to heat; response to peptide hormone stimulus; translational initiation Disease: Leukoencephalopathy With Vanishing White Matter |
NCBI Summary: | This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009] |
UniProt Code: | Q13144 |
NCBI GenInfo Identifier: | 160359049 |
NCBI Gene ID: | 8893 |
NCBI Accession: | Q13144.3 |
UniProt Secondary Accession: | Q13144,Q541Z1, Q96D04, |
UniProt Related Accession: | Q13144 |
Molecular Weight: | 80kDa |
NCBI Full Name: | Translation initiation factor eIF-2B subunit epsilon |
NCBI Synonym Full Names: | eukaryotic translation initiation factor 2B subunit epsilon |
NCBI Official Symbol: | EIF2B5 |
NCBI Official Synonym Symbols: | CLE; CACH; LVWM; EIF-2B; EIF2Bepsilon |
NCBI Protein Information: | translation initiation factor eIF-2B subunit epsilon |
UniProt Protein Name: | Translation initiation factor eIF-2B subunit epsilon |
UniProt Synonym Protein Names: | eIF-2B GDP-GTP exchange factor subunit epsilon |
Protein Family: | Translation initiation factor |
UniProt Gene Name: | EIF2B5 |