Anti-EIF2B3 Antibody (CAB10262)
- SKU:
- CAB10262
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-EIF2B3 Antibody |
抗体コード: | CAB10262 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human EIF2B3 (NP_065098.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:1000 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HepG2, K-562, HT-29, Mouse heart, Mouse lung, Mouse brain, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human EIF2B3 (NP_065098.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MEFQ AVVM AVGG GSRM TDLT SSIP KPLL PVGN KPLI WYPL NLLE RVGF EEVI VVTT RDVQ KALC AEFK MKMK PDIV CIPD DADM GTAD SLRY IYPK LKTD VLVL SCDL ITDV ALHE VVDL FRAY DASL AMLM RKGQ DSIE PVPG QKGK KKAV EQRD FIGV DSTG KRLL FMAN EADL DEEL VIKG SILQ KHPR IRFH TGLV DAHL YCLK KYIV DFLM ENGS ITSI RSEL IPYL VRKQ FSSA SSQQ GQEE KEED LKKK ELKS LDIY SFIK EA |
遺伝子ID: | 8891 |
Uniprot: | Q9NR50 |
セルラーロケーション: | |
計算された分子量: | 44kDa/46kDa/50kDa |
観察された分子量: | 50kDa |
同義語: | EIF2B3, EIF-2B, EIF2Bgamma |
バックグラウンド: | The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | eIF2B-gamma: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Defects in EIF2B3 are a cause of leukodystrophy with vanishing white matter (VWM). VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy. Belongs to the eIF-2B gamma/epsilon subunits family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Translation; Translation initiation Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 2B complex Molecular Function:guanyl-nucleotide exchange factor activity; protein binding; translation factor activity, nucleic acid binding; translation initiation factor activity Biological Process: cellular response to stimulus; negative regulation of translation initiation in response to stress; oligodendrocyte development; response to glucose stimulus; response to heat; response to peptide hormone stimulus; translational initiation Disease: Leukoencephalopathy With Vanishing White Matter |
NCBI Summary: | The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] |
UniProt Code: | Q9NR50 |
NCBI GenInfo Identifier: | 18203317 |
NCBI Gene ID: | 8891 |
NCBI Accession: | Q9NR50.1 |
UniProt Secondary Accession: | Q9NR50,Q5QP89, Q5QP90, Q8NDB5, Q8WV57, Q9H850, B2RBH8 D3DPZ2, |
UniProt Related Accession: | Q9NR50 |
Molecular Weight: | 50kDa |
NCBI Full Name: | Translation initiation factor eIF-2B subunit gamma |
NCBI Synonym Full Names: | eukaryotic translation initiation factor 2B subunit gamma |
NCBI Official Symbol: | EIF2B3 |
NCBI Official Synonym Symbols: | EIF-2B; EIF2Bgamma |
NCBI Protein Information: | translation initiation factor eIF-2B subunit gamma |
UniProt Protein Name: | Translation initiation factor eIF-2B subunit gamma |
UniProt Synonym Protein Names: | eIF-2B GDP-GTP exchange factor subunit gamma |
Protein Family: | Translation initiation factor |
UniProt Gene Name: | EIF2B3 |
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