Anti-DSC1 Antibody (CAB10061)
- SKU:
- CAB10061
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-DSC1 Antibody |
抗体コード: | CAB10061 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 480-690 of human DSC1 (NP_077739.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Raji, Mouse liver, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 480-690 of human DSC1 (NP_077739.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | SQDG FPAG QELL GYKA LDPE ISSG EGLR YQKL GDED NWFE INQH TGDL RTLK VLDR ESKF VKNN QYNI SVVA VDAV GRSC TGTL VVHL DDYN DHAP QIDK EVTI CQNN EDFA VLKP VDPD GPEN GPPF QFFL DNSA SKNW NIEE KDGK TAIL RQRQ NLDY NYYS VPIQ IKDR HGLV ATHM LTVR VCDC STPS ECRM KDKS TRDV RPNV ILG |
遺伝子ID: | 1823 |
Uniprot: | Q08554 |
セルラーロケーション: | Cell junction, Cell membrane, Single-pass type I membrane protein, desmosome |
計算された分子量: | 93kDa/99kDa |
観察された分子量: | 105kDa |
同義語: | DSC1, CDHF1, DG2/DG3 |
バックグラウンド: | The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein. |
UniProt Protein Function: | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. |
NCBI Summary: | The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein. [provided by RefSeq, Nov 2015] |
UniProt Code: | Q08554 |
NCBI GenInfo Identifier: | 223590198 |
NCBI Gene ID: | 1823 |
NCBI Accession: | Q08554.2 |
UniProt Secondary Accession: | Q08554,Q9HB01, |
UniProt Related Accession: | Q08554 |
Molecular Weight: | 93,835 Da |
NCBI Full Name: | Desmocollin-1 |
NCBI Synonym Full Names: | desmocollin 1 |
NCBI Official Symbol: | DSC1 |
NCBI Official Synonym Symbols: | CDHF1; DG2/DG3 |
NCBI Protein Information: | desmocollin-1 |
UniProt Protein Name: | Desmocollin-1 |
UniProt Synonym Protein Names: | Cadherin family member 1; Desmosomal glycoprotein 2/3; DG2/DG3 |
Protein Family: | Desmocollin |
UniProt Gene Name: | DSC1 |
UniProt Entry Name: | DSC1_HUMAN |
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