Anti-DHDDS Antibody (CAB7835)
- SKU:
- CAB7835
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-DHDDS Antibody |
抗体コード: | CAB7835 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human DHDDS (NP_995583.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | 293T, Mouse testis, Rat thymus |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human DHDDS (NP_995583.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | IKAG PMPK HIAF IMDG NRRY AKKC QVER QEGH SQGF NKLA ETLR WCLN LGIL EVTV YAFS IENF KRSK SEVD GLMD LARQ KFSR LMEE KEKL QKHG VCIR VLGD LHLL PLDL QELI AQAV QATK NYNK CFLN VCFA YTSR HEIS NAVR EMAW GVEQ GLLD PSDI SESL LDKC LYTN RSPH P |
遺伝子ID: | 79947 |
Uniprot: | Q86SQ9 |
セルラーロケーション: | Endoplasmic reticulum membrane, Peripheral membrane protein |
計算された分子量: | 34kDa/38kDa |
観察された分子量: | 34kDa |
同義語: | DHDDS, CIT, CPT, DS, HDS, RP59 |
バックグラウンド: | The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
UniProt Protein Function: | DHDDS: Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for the biosynthesis of several classes of glycoprotein. Defects in DHDDS are the cause of retinitis pigmentosa type 59 (RP59). RP59 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the UPP synthase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Transferase; EC 2.5.1.87 Chromosomal Location of Human Ortholog: 1p36.11 Cellular Component: endoplasmic reticulum membrane Molecular Function:transferase activity, transferring alkyl or aryl (other than methyl) groups; protein binding Biological Process: cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; dolichyl diphosphate biosynthetic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification Disease: Retinitis Pigmentosa 59 |
NCBI Summary: | The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
UniProt Code: | Q86SQ9 |
NCBI GenInfo Identifier: | 343790880 |
NCBI Gene ID: | 79947 |
NCBI Accession: | NP_001230494.1 |
UniProt Related Accession: | Q86SQ9 |
Molecular Weight: | 39kDa |
NCBI Full Name: | dehydrodolichyl diphosphate synthase complex subunit DHDDS isoform 4 |
NCBI Synonym Full Names: | dehydrodolichyl diphosphate synthase subunit |
NCBI Official Symbol: | DHDDS |
NCBI Official Synonym Symbols: | DS; CIT; CPT; HDS; RP59; hCIT; DEDSM |
NCBI Protein Information: | dehydrodolichyl diphosphate synthase complex subunit DHDDS |
UniProt Protein Name: | Dehydrodolichyl diphosphate synthase |
UniProt Synonym Protein Names: | Cis-isoprenyltransferase; CIT; Cis-IPTase; Epididymis tissue protein Li 189m |
Protein Family: | Dehydrodolichyl diphosphate synthase complex |
UniProt Gene Name: | DHDDS |
UniProt Entry Name: | DHDDS_HUMAN |
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