Anti-DEDD Antibody (CAB5806)
- SKU:
- CAB5806
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
抗体名: | Anti-DEDD Antibody |
抗体コード: | CAB5806 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of human DEDD (NP_001034801.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of human DEDD (NP_001034801.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAGL KRRA SQVW PEEH GEQE HGLY SLHR MFDI VGTH LTHR DVRV LSFL FVDV IDDH ERGL IRNG RDFL LALE RQGR CDES NFRQ VLQL LRII TRHD LLPY VTLK RRRA VCPD LVDK YLEE TSIR YVTP RALS DPEP RPPQ PSKT VPPH YPVV CCPT SGPQ MCSK RPAR GRAT LGSQ RKRR KSVT PDPK EKQT CDIR LRVR AEYC QHET ALQG NVFS NKQD PLER QFER FNQA NTIL KSRD LGSI ICDI KFSE LTYL DAFW RDYI NGSL LEAL KGVF ITDS LKQA VGHE AIKL LVNV DEED YELG RQKL LRNL MLQA LP |
遺伝子ID: | 9191 |
Uniprot: | O75618 |
セルラーロケーション: | Cytoplasm, Nucleus, nucleolus |
計算された分子量: | 36kDa/40kDa |
観察された分子量: | Refer to Figures |
同義語: | DEDD, CASP8IP1, DEDD1, DEFT, FLDED1, KE05 |
バックグラウンド: | This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. |
UniProt Protein Function: | DEDD: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nucleolus Chromosomal Location of Human Ortholog: 1q23.3 Cellular Component: cytoplasm; nucleolus Molecular Function:DNA binding; protein binding |
NCBI Summary: | This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O75618 |
NCBI GenInfo Identifier: | 21759089 |
NCBI Gene ID: | 9191 |
NCBI Accession: | O75618.1 |
UniProt Secondary Accession: | O75618,O60737, D3DVF5, |
UniProt Related Accession: | O75618 |
Molecular Weight: | 40,418 Da |
NCBI Full Name: | Death effector domain-containing protein |
NCBI Synonym Full Names: | death effector domain containing |
NCBI Official Symbol: | DEDD |
NCBI Official Synonym Symbols: | DEFT; KE05; DEDD1; FLDED1; CASP8IP1 |
NCBI Protein Information: | death effector domain-containing protein |
UniProt Protein Name: | Death effector domain-containing protein |
UniProt Synonym Protein Names: | DEDPro1; Death effector domain-containing testicular molecule; FLDED-1 |
Protein Family: | Death effector domain-containing protein |
UniProt Gene Name: | DEDD |
UniProt Entry Name: | DEDD_HUMAN |
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