Anti-DDC Antibody (CAB3828)
- SKU:
- CAB3828
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
抗体名: | Anti-DDC Antibody |
抗体コード: | CAB3828 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human DDC (NP_000781.1). |
申し込み: | WB |
推奨希釈: | WB 1:200 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HepG2, SW620, PC-12, Mouse liver, Mouse kidney, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human DDC (NP_000781.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MNAS EFRR RGKE MVDY VANY MEGI EGRQ VYPD VEPG YLRP LIPA AAPQ EPDT FEDI INDV EKII MPGV THWH SPYF FAYF PTAS SYPA MLAD MLCG AIGC |
遺伝子ID: | 1644 |
Uniprot: | P20711 |
セルラーロケーション: | |
計算された分子量: | 37kDa/44kDa/45kDa/53kDa |
観察された分子量: | 54-56kDa |
同義語: | DDC, AADC |
バックグラウンド: | The encoded protein catalyzes the decarboxylation of L-3, 4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. |
UniProt Protein Function: | DDC: Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Homodimer. Belongs to the group II decarboxylase family. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - tryptophan; EC 4.1.1.28; Amino Acid Metabolism - histidine; Amino Acid Metabolism - tyrosine; Nuclear receptor co-regulator; Amino Acid Metabolism - phenylalanine; Lyase Chromosomal Location of Human Ortholog: 7p12.2 Cellular Component: synaptic vesicle; cell soma; axon; cytosol Molecular Function:aromatic-L-amino-acid decarboxylase activity; protein domain specific binding; amino acid binding; protein binding; enzyme binding; pyridoxal phosphate binding Biological Process: circadian rhythm; amino acid metabolic process; catecholamine biosynthetic process; indolalkylamine biosynthetic process; multicellular organismal aging; isoquinoline alkaloid metabolic process; dopamine biosynthetic process; serotonin biosynthetic process; phytoalexin metabolic process; synaptic vesicle amine transport; response to pyrethroid Disease: Aromatic L-amino Acid Decarboxylase Deficiency |
NCBI Summary: | The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011] |
UniProt Code: | P20711 |
NCBI GenInfo Identifier: | 311033369 |
NCBI Gene ID: | 1644 |
NCBI Accession: | P20711.2 |
UniProt Secondary Accession: | P20711,O88533, P14173, |
UniProt Related Accession: | P20711 |
Molecular Weight: | 480 |
NCBI Full Name: | Aromatic-L-amino-acid decarboxylase |
NCBI Synonym Full Names: | dopa decarboxylase (aromatic L-amino acid decarboxylase) |
NCBI Official Symbol: | DDC |
NCBI Official Synonym Symbols: | AADC |
NCBI Protein Information: | aromatic-L-amino-acid decarboxylase |
UniProt Protein Name: | Aromatic-L-amino-acid decarboxylase |
UniProt Synonym Protein Names: | DOPA decarboxylase; DDC |
Protein Family: | Aromatic-L-amino-acid decarboxylase |
UniProt Gene Name: | DDC |
UniProt Entry Name: | DDC_HUMAN |