Anti-DBH Antibody (CAB2711)
- SKU:
- CAB2711
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
抗体名: | Anti-DBH Antibody |
抗体コード: | CAB2711 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human DBH (NP_000778.3). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:1000 IHC 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Mouse brain |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human DBH (NP_000778.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | PFGT CDPK DYLI EDGT VHLV YGIL EEPF RSLE AING SGLQ MGLQ RVQL LKPN IPEP ELPS DACT MEVQ APNI QIPS QETT YWCY IKEL PKGF SRHH IIKY E |
遺伝子ID: | 1621 |
Uniprot: | P09172 |
セルラーロケーション: | Cytoplasmic vesicle, Single-pass type II membrane protein, chromaffin granule lumen, chromaffin granule membrane, secretory vesicle, secretory vesicle lumen, secretory vesicle membrane |
計算された分子量: | 69kDa |
観察された分子量: | 79kDa |
同義語: | DBH, DBM |
バックグラウンド: | The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. |
UniProt Protein Function: | DBH: Conversion of dopamine to noradrenaline. Homotetramer composed of two non-covalently bound disulfide-linked dimers. Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids. Belongs to the copper type II ascorbate-dependent monooxygenase family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; EC 1.14.17.1; Oxidoreductase; Apoptosis; Amino Acid Metabolism - tyrosine; Cell cycle regulation Chromosomal Location of Human Ortholog: 9q34 Cellular Component: membrane; cytoplasm; integral to membrane; extracellular region Molecular Function:copper ion binding; L-ascorbic acid binding; dopamine beta-monooxygenase activity; catalytic activity Biological Process: fear response; dopamine catabolic process; maternal behavior; response to amphetamine; cytokine production; locomotory behavior; response to pain; behavioral response to ethanol; leukocyte mediated immunity; glucose homeostasis; memory; regulation of cell proliferation; norepinephrine biosynthetic process; synaptic transmission; catecholamine biosynthetic process; homoiothermy; positive regulation of vasoconstriction; visual learning; blood vessel remodeling; leukocyte migration Disease: Dopamine Beta-hydroxylase Deficiency, Congenital |
NCBI Summary: | The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017] |
UniProt Code: | P09172 |
NCBI GenInfo Identifier: | 158517849 |
NCBI Gene ID: | 1621 |
NCBI Accession: | P09172.3 |
UniProt Related Accession: | P09172 |
Molecular Weight: | |
NCBI Full Name: | Dopamine beta-hydroxylase |
NCBI Synonym Full Names: | dopamine beta-hydroxylase |
NCBI Official Symbol: | DBH |
NCBI Official Synonym Symbols: | DBM; ORTHYP1 |
NCBI Protein Information: | dopamine beta-hydroxylase |
UniProt Protein Name: | Dopamine beta-hydroxylase |
UniProt Synonym Protein Names: | Dopamine beta-monooxygenaseSoluble dopamine beta-hydroxylase |
Protein Family: | Dopamine beta-hydroxylase |
UniProt Gene Name: | DBH |
UniProt Entry Name: | DOPO_HUMAN |