Anti-CYTH4 Antibody (CAB14875)
- SKU:
- CAB14875
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-CYTH4 Antibody |
抗体コード: | CAB14875 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human CYTH4 (NP_037517.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse liver, Mouse brain, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human CYTH4 (NP_037517.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MDLC HPEP AELS SGET EELQ RIKW HRKQ LLED IQKL KDEI ADVF AQID CFES AEES RMAQ KEKE LCIG RK |
遺伝子ID: | 27128 |
Uniprot: | Q9UIA0 |
セルラーロケーション: | Cell membrane, Peripheral membrane protein |
計算された分子量: | 45kDa |
観察された分子量: | 46kDa |
同義語: | CYTH4, CYT4, DJ63G5.1, PSCD4 |
バックグラウンド: | This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene. |
UniProt Protein Function: | cytohesin 4: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through replacement of GDP with GTP. |
UniProt Protein Details: | Protein type:GEFs; GEFs, ARF Chromosomal Location of Human Ortholog: 22q12.3-q13.1 Cellular Component: cytosol; Golgi membrane; plasma membrane Molecular Function:ARF guanyl-nucleotide exchange factor activity |
NCBI Summary: | This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015] |
UniProt Code: | Q9UIA0 |
NCBI GenInfo Identifier: | 13124094 |
NCBI Gene ID: | 27128 |
NCBI Accession: | Q9UIA0.1 |
UniProt Secondary Accession: | Q9UIA0,Q5R3F9, Q9UGT6, |
UniProt Related Accession: | Q9UIA0 |
Molecular Weight: | 45,672 Da |
NCBI Full Name: | Cytohesin-4 |
NCBI Synonym Full Names: | cytohesin 4 |
NCBI Official Symbol: | CYTH4 |
NCBI Official Synonym Symbols: | CYT4; PSCD4; DJ63G5.1 |
NCBI Protein Information: | cytohesin-4 |
UniProt Protein Name: | Cytohesin-4 |
UniProt Synonym Protein Names: | PH, SEC7 and coiled-coil domain-containing protein 4 |
Protein Family: | Cytohesin |
UniProt Gene Name: | CYTH4 |
UniProt Entry Name: | CYH4_HUMAN |
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