Anti-CYP4A11 Antibody (CAB5459)
- SKU:
- CAB5459
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
抗体名: | Anti-CYP4A11 Antibody |
抗体コード: | CAB5459 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CYP4A11 (NP_000769.2). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
反応性: | Human, Mouse |
ポジティブサンプル: |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CYP4A11 (NP_000769.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSVS VLSP SRLL GDVS GILQ AASL LILL LLLI KAVQ LYLH RQWL LKAL QQFP CPPS HWLF GHIQ ELQQ DQEL QRIQ KWVE TFPS ACPH WLWG GKVR VQLY DPDY MKVI LGRS DPKS HGSY RFLA PWIG YGLL LLNG QTWF QHRR MLTP AFHY DILK PYVG LMAD SVRV MLDK WEEL LGQD SPLE VFQH VSLM TLDT IMKC |
遺伝子ID: | 1579 |
Uniprot: | Q02928 |
セルラーロケーション: | Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein |
計算された分子量: | 41kDa/59kDa |
観察された分子量: | Refer to figures |
同義語: | CYP4A11, CP4Y, CYP4A2, CYP4AII |
バックグラウンド: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. |
UniProt Protein Function: | CYP4A11: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Endoplasmic reticulum; Oxidoreductase; Lipid Metabolism - fatty acid; Lipid Metabolism - arachidonic acid; EC 1.14.15.3; Cofactor and Vitamin Metabolism - retinol Chromosomal Location of Human Ortholog: 1p33 Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; apical plasma membrane; cytoplasm Molecular Function:leukotriene-B4 20-monooxygenase activity; iron ion binding; heme binding; arachidonic acid epoxygenase activity; alkane 1-monooxygenase activity Biological Process: xenobiotic metabolic process; positive regulation of icosanoid secretion; renal water homeostasis; arachidonic acid metabolic process; leukotriene metabolic process; sodium ion homeostasis; epoxygenase P450 pathway; cellular lipid metabolic process; long-chain fatty acid metabolic process; fatty acid metabolic process; pressure natriuresis |
NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q02928 |
NCBI GenInfo Identifier: | 2493371 |
NCBI Gene ID: | 1579 |
NCBI Accession: | Q02928.1 |
UniProt Secondary Accession: | Q02928,Q06766, Q16865, Q16866, Q5VSP8, Q86SU6, Q8IWY5 |
UniProt Related Accession: | Q02928 |
Molecular Weight: | 519 |
NCBI Full Name: | Cytochrome P450 4A11 |
NCBI Synonym Full Names: | cytochrome P450, family 4, subfamily A, polypeptide 11 |
NCBI Official Symbol: | CYP4A11 |
NCBI Official Synonym Symbols: | CP4Y; CYP4A2; CYP4AII |
NCBI Protein Information: | cytochrome P450 4A11; CYPIVA11; P450HL-omega; 20-HETE synthase; alkane-1 monooxygenase; cytochrome P450HL-omega; cytochrome P-450HK-omega; fatty acid omega-hydroxylase; lauric acid omega-hydroxylase; 20-hydroxyeicosatetraenoic acid synthase; cytochrome P450, subfamily IVA, polypeptide 11 |
UniProt Protein Name: | Cytochrome P450 4A11 |
UniProt Synonym Protein Names: | 20-hydroxyeicosatetraenoic acid synthase; 20-HETE synthase; CYP4AII; CYPIVA11; Cytochrome P-450HK-omega; Cytochrome P450HL-omega; Fatty acid omega-hydroxylase; Lauric acid omega-hydroxylase (EC:1.14.15.3) |
Protein Family: | Cytochrome |
UniProt Gene Name: | CYP4A11 |
UniProt Entry Name: | CP4AB_HUMAN |
Immunohistochemistry of paraffin-embedded mouse kidney using CYP4A11 antibody (CAB5459) at dilution of 1:100 (40x lens). |