Anti-CRBN Antibody (CAB4722)

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SKU:
CAB4722
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CRBN
Synonyms:
MRT2
Synonyms:
MRT2A
Synonyms:
cereblon
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Description

抗体名:CRBN Rabbit pAb
抗体コード:CAB4722
サイズ:20uL, 50uL, 100uL
同義語:CRBN, MRT2, MRT2A, cereblon
申し込み:WB
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human CRBN (NP_001166953.1).
申し込み:WB
推奨される希釈:WB 1:200 - 1:2000
反応性:Human, Mouse, Rat
ポジティブサンプル:U-87MG, A-549, Mouse brain, Rat brain
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human CRBN (NP_001166953.1).
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:MAGE GDQQ DAAH NMGN HLPL LPES EEED EMEV EDQD SKEA KKPN IINF DTSL PTSH TYLG ADME EFHG RTLH DDDS CQVI PVLP QVMM ILIP GQTL PLQL FHPQ EVSM VRNL IQKD RTFA VLAY SNVQ EREA QFGT TAEI YAYR EEQD FGIE IVKV KAIG RQRF KVLE LRTQ SDGI QQAK VQIL PECV LPST MSAV QLES LNKC QIFP SKPV SRED QCSY KWWQ KYQK RKFH CANL TSWP RWLY SLYD AETL MDRI KKQL REWD ENLK DDSL PSNP IDFS
遺伝子ID:51185
Uniprot:Q96SW2
セルラーロケーション:Cytoplasm, Membrane, Nucleus, Peripheral membrane protein
計算された分子量:50kDa
観察された分子量:55KDa
UniProt Protein Function:CRBN: Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Defects in CRBN are the cause of mental retardation autosomal recessive type 2A (MRT2A). MRT2A patients display mild mental retardation with a standard IQ ranged from 50 to 70. IQ scores are lower in males than females. Developmental milestones are mildly delayed. There are no dysmorphic or autistic features. Non-syndromic mental retardation patients do not manifest other clinical signs. Belongs to the CRBN family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 3p26.2

Cellular Component: membrane; cytoplasm; nucleolus; nucleus

Molecular Function:protein binding; ATP-dependent peptidase activity; metal ion binding

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; negative regulation of protein homooligomerization

Disease: Mental Retardation, Autosomal Recessive 2

NCBI Summary:This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Code:Q96SW2
NCBI GenInfo Identifier:73918916
NCBI Gene ID:51185
NCBI Accession:Q96SW2.1
UniProt Secondary Accession:Q96SW2,Q6AI62, Q6NVZ0, Q9UHW4, B2R6H4, C9IZA9, C9JAH6
UniProt Related Accession:Q96SW2
Molecular Weight:442
NCBI Full Name:Protein cereblon
NCBI Synonym Full Names:cereblon
NCBI Official Symbol:CRBN  
NCBI Official Synonym Symbols:MRT2; MRT2A  
NCBI Protein Information:protein cereblon; protein x 0001
UniProt Protein Name:Protein cereblon
Protein Family:Protein cereblon
UniProt Gene Name:CRBN  
UniProt Entry Name:CRBN_HUMAN
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