Anti-CPNE1 Antibody (CAB15749)
- SKU:
- CAB15749
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
抗体名: | Anti-CPNE1 Antibody |
抗体コード: | CAB15749 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-220 of human CPNE1 (NP_003906.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse brain, Mouse heart, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-220 of human CPNE1 (NP_003906.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MLKP GKPA GRGT ITVS AQEL KDNR VVTM EVEA RNLD KKDF LGKS DPFL EFFR QGDG KWHL VYRS EVIK NNLN PTWK RFSV PVQH FCGG NPST PIQV QCSD Y |
遺伝子ID: | 8904 |
Uniprot: | Q99829 |
セルラーロケーション: | Cell membrane, Cytoplasm, Nucleus |
計算された分子量: | 59kDa |
観察された分子量: | 65kDa |
同義語: | CPNE1, COPN1, CPN1, copine-1 |
バックグラウンド: | Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins. |
UniProt Protein Function: | Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740). |
NCBI Summary: | Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Aug 2008] |
UniProt Code: | Q99829 |
NCBI GenInfo Identifier: | 197333761 |
NCBI Gene ID: | 8904 |
NCBI Accession: | NP_003906.2 |
UniProt Secondary Accession: | Q99829,Q6IBL3, Q9H243, Q9NTZ7, E1P5Q4, |
UniProt Related Accession: | Q99829 |
Molecular Weight: | 59,059 Da |
NCBI Full Name: | copine-1 isoform b |
NCBI Synonym Full Names: | copine 1 |
NCBI Official Symbol: | CPNE1 |
NCBI Official Synonym Symbols: | CPN1; COPN1 |
NCBI Protein Information: | copine-1 |
UniProt Protein Name: | Copine-1 |
UniProt Synonym Protein Names: | Chromobindin 17 |
Protein Family: | Carboxypeptidase |
UniProt Gene Name: | CPNE1 |
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