Anti-CNTF Antibody (CAB1915)
- SKU:
- CAB1915
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Frequently bought together:
Description
抗体名: | Anti-CNTF Antibody |
抗体コード: | CAB1915 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CNTF (NP_000605.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Mouse skeletal muscle |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CNTF (NP_000605.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAFT EHSP LTPH RRDL CSRS IWLA RKIR SDLT ALTE SYVK HQGL NKNI NLDS ADGM PVAS TDQW SELT EAER LQEN LQAY RTFH VLLA RLLE DQQV HFTP TEGD FHQA IHTL LLQV AAFA YQIE ELMI LLEY KIPR NEAD GMPI NVGD GGLF EKKL WGLK VLQE LSQW TVRS IHDL RFIS SHQT GIPA RGSH YIAN NKKM |
遺伝子ID: | 1270 |
Uniprot: | P26441 |
セルラーロケーション: | Cytoplasm |
計算された分子量: | 22kDa |
観察された分子量: | 26kDa |
同義語: | CNTF, HCNTF |
バックグラウンド: | The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. |
UniProt Protein Function: | CNTF: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. Belongs to the CNTF family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 11q12.2 Cellular Component: cytoplasm; extracellular region; extracellular space Molecular Function:ciliary neurotrophic factor receptor binding; growth factor activity; interleukin-6 receptor binding; protein binding Biological Process: growth; muscle morphogenesis; negative regulation of neuron apoptosis; negative regulation of photoreceptor cell differentiation; neuron development; positive regulation of cell proliferation; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of retinal cell programmed cell death; signal transduction |
NCBI Summary: | The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010] |
UniProt Code: | P26441 |
NCBI GenInfo Identifier: | 116585 |
NCBI Gene ID: | 1270 |
NCBI Accession: | P26441.1 |
UniProt Secondary Accession: | P26441,B2RAB2, |
UniProt Related Accession: | P26441 |
Molecular Weight: | |
NCBI Full Name: | Ciliary neurotrophic factor |
NCBI Synonym Full Names: | ciliary neurotrophic factor |
NCBI Official Symbol: | CNTF |
NCBI Official Synonym Symbols: | HCNTF |
NCBI Protein Information: | ciliary neurotrophic factor |
UniProt Protein Name: | Ciliary neurotrophic factor |
Protein Family: | Ciliary neurotrophic factor |
UniProt Gene Name: | CNTF |
UniProt Entry Name: | CNTF_HUMAN |
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