Anti-CLDN19 Antibody (CAB2874)
- SKU:
- CAB2874
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-CLDN19 Antibody |
抗体コード: | CAB2874 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-80 of human CLDN19 (NP_001116867.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | 293T, Mouse kidney |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-80 of human CLDN19 (NP_001116867.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | GIIA STAL PQWK QSSY AGDA IITA VGLY EGLW MSCA SQST GQVQ CKLY DSLL ALDG HIQS A |
遺伝子ID: | 149461 |
Uniprot: | Q8N6F1 |
セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, tight junction |
計算された分子量: | 22kDa/23kDa |
観察された分子量: | 23kDa |
同義語: | CLDN19, HOMG5 |
バックグラウンド: | The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. |
UniProt Protein Function: | Claudin-19: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Defects in CLDN19 are the cause of hypomagnesemia renal with ocular involvement (HOMG5). HOMG5 is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. The renal phenotype is virtually undistinguishable from that of patients with HOMG3 with proven CLDN16 mutations. Belongs to the claudin family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 1p34.2 Cellular Component: apical junction complex; tight junction; basolateral plasma membrane; cytoplasm; integral to membrane; nucleus Molecular Function:identical protein binding; structural molecule activity Biological Process: apical junction assembly; visual perception; response to stimulus; action potential propagation; calcium-independent cell-cell adhesion Disease: Hypomagnesemia 5, Renal, With Ocular Involvement |
NCBI Summary: | The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010] |
UniProt Code: | Q8N6F1 |
NCBI GenInfo Identifier: | 47606757 |
NCBI Gene ID: | 149461 |
NCBI Accession: | Q8N6F1.2 |
UniProt Secondary Accession: | Q8N6F1,Q5QT57, Q8N8X0, B7Z5I2, F5H5P9, |
UniProt Related Accession: | Q8N6F1 |
Molecular Weight: | 224 |
NCBI Full Name: | Claudin-19 |
NCBI Synonym Full Names: | claudin 19 |
NCBI Official Symbol: | CLDN19 |
NCBI Official Synonym Symbols: | HOMG5 |
NCBI Protein Information: | claudin-19 |
UniProt Protein Name: | Claudin-19 |
Protein Family: | Claudin |
UniProt Gene Name: | CLDN19 |
UniProt Entry Name: | CLD19_HUMAN |
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