Anti-CHST6 Antibody (CAB10229)
- SKU:
- CAB10229
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-CHST6 Antibody |
抗体コード: | CAB10229 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 196-395 of human CHST6 (NP_067628.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-87MG, MCF7 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 196-395 of human CHST6 (NP_067628.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | RIVH LVRD PRAV LRSR EQTA KALA RDNG IVLG TNGT WVEA DPGL RVVR EVCR SHVR IAEA ATLK PPPF LRGR YRLV RFED LARE PLAE IRAL YAFT GLSL TPQL EAWI HNIT HGSG PGAR REAF KTSS RNAL NVSQ AWRH ALPF AKIR RVQE LCAG ALQL LGYR PVYS EDEQ RNLA LDLV LPRG LNGF TWAS STAS HPRN |
遺伝子ID: | 4166 |
Uniprot: | Q9GZX3 |
セルラーロケーション: | Golgi apparatus membrane, Single-pass type II membrane protein |
計算された分子量: | 44kDa |
観察された分子量: | 44kDa |
同義語: | CHST6, MCDC1 |
バックグラウンド: | The protein encoded by this gene is an enzyme that catalyzes the transfer of a sulfate group to the GlcNAc residues of keratan. Keratan sulfate helps maintain corneal transparency. Defects in this gene are a cause of macular corneal dystrophy (MCD). |
UniProt Protein Function: | CHST6: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N- acetyllactosamine structures. Defects in CHST6 are the cause of macular corneal dystrophy (MCD). MCD is an autosomal recessive disease characterized by corneal opacities. Onset occurs in the first decade, usually between ages 5 and 9. The disorder is progressive. Minute, gray, punctate opacities develop. Corneal sensitivity is usually reduced. Painful attacks with photophobia, foreign body sensations, and recurrent erosions occur in most patients. There are different types of MCD: MCD type I, in which there is a virtual absence of sulfated keratan sulfate (KS) in the serum and cornea, as determined by KS-specific antibodies; and MCD type II, in which the normal sulfated KS-antibody response is present in cornea and serum. MCD type I patients usually have a homozygous missense mutation, while MCD type II patients show a large deletion and replacement in the upstream region of CHST6. The only missense mutation for type II is Cys-50, which is heterozygous with a replacement in the upstream region on the other allele of CHST6. Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily. |
UniProt Protein Details: | Protein type:Glycan Metabolism - keratan sulfate biosynthesis; Transferase; Membrane protein, integral; EC 2.8.2.- Chromosomal Location of Human Ortholog: 16q22 Cellular Component: Golgi apparatus; Golgi membrane; integral to membrane Molecular Function:N-acetylglucosamine 6-O-sulfotransferase activity Biological Process: keratan sulfate biosynthetic process; N-acetylglucosamine metabolic process; sulfur metabolic process Disease: Macular Dystrophy, Corneal, 1 |
NCBI Summary: | The protein encoded by this gene is an enzyme that catalyzes the transfer of a sulfate group to the GlcNAc residues of keratan. Keratan sulfate helps maintain corneal transparency. Defects in this gene are a cause of macular corneal dystrophy (MCD). [provided by RefSeq, Jan 2010] |
UniProt Code: | Q9GZX3 |
NCBI GenInfo Identifier: | 61212105 |
NCBI Gene ID: | 4166 |
NCBI Accession: | Q9GZX3.1 |
UniProt Secondary Accession: | Q9GZX3,D3DUK3, |
UniProt Related Accession: | Q9GZX3 |
Molecular Weight: | 44,099 Da |
NCBI Full Name: | Carbohydrate sulfotransferase 6 |
NCBI Synonym Full Names: | carbohydrate sulfotransferase 6 |
NCBI Official Symbol: | CHST6 |
NCBI Official Synonym Symbols: | MCDC1 |
NCBI Protein Information: | carbohydrate sulfotransferase 6 |
UniProt Protein Name: | Carbohydrate sulfotransferase 6 |
UniProt Synonym Protein Names: | Corneal N-acetylglucosamine-6-O-sulfotransferase; C-GlcNAc6ST; hCGn6ST; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta; GST4-beta; N-acetylglucosamine 6-O-sulfotransferase 5; GlcNAc6ST-5; Gn6st-5 |
Protein Family: | Carbohydrate sulfotransferase |
UniProt Gene Name: | CHST6 |
UniProt Entry Name: | CHST6_HUMAN |
View AllClose