Anti-CHRNA2 Antibody (CAB10056)
- SKU:
- CAB10056
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-CHRNA2 Antibody |
抗体コード: | CAB10056 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-264 of human CHRNA2 (NP_000733.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Rat |
ポジティブサンプル: | Rat skeletal muscle |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-264 of human CHRNA2 (NP_000733.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | EEAK RPPP RAPG DPLS SPSP TALP QGGS HTET EDRL FKHL FRGY NRWA RPVP NTSD VVIV RFGL SIAQ LIDV DEKN QMMT TNVW LKQE WSDY KLRW NPTD FGNI TSLR VPSE MIWI PDIV LYNN ADGE FAVT HMTK AHLF STGT VHWV PPAI YKSS CSID VTFF PFDQ QNCK MKFG SWTY DKAK IDLE QMEQ TVDL KDYW ESGE WAIV NATG TYNS KKYD CCAE IYPD VTYA FVIR RL |
遺伝子ID: | 1135 |
Uniprot: | Q15822 |
セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
計算された分子量: | 58kDa/59kDa |
観察された分子量: | 60kDa |
同義語: | CHRNA2 |
バックグラウンド: | Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. |
UniProt Protein Function: | nAChRA2: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in CHRNA2 are the cause of nocturnal frontal lobe epilepsy type 4 (ENFL4). ENFL4 is an autosomal dominant epilepsy characterized by nocturnal seizures associated with fear sensation, tongue movements, and nocturnal wandering, closely resembling nightmares and sleep walking. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 2/CHRNA2 sub-subfamily. |
UniProt Protein Details: | Protein type:Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Chromosomal Location of Human Ortholog: 8p21 Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; plasma membrane Molecular Function:acetylcholine binding; acetylcholine receptor activity; ligand-gated ion channel activity; nicotinic acetylcholine-activated cation-selective channel activity Biological Process: neuromuscular synaptic transmission; response to nicotine; signal transduction; synaptic transmission, cholinergic Disease: Epilepsy, Nocturnal Frontal Lobe, 4 |
NCBI Summary: | Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009] |
UniProt Code: | Q15822 |
NCBI GenInfo Identifier: | 308153405 |
NCBI Gene ID: | 1135 |
NCBI Accession: | Q15822.2 |
UniProt Secondary Accession: | Q15822,Q9HAQ3, A8KAX3, B4DK19, J3KMY9, |
UniProt Related Accession: | Q15822 |
Molecular Weight: | 58,140 Da |
NCBI Full Name: | Neuronal acetylcholine receptor subunit alpha-2 |
NCBI Synonym Full Names: | cholinergic receptor nicotinic alpha 2 subunit |
NCBI Official Symbol: | CHRNA2 |
NCBI Protein Information: | neuronal acetylcholine receptor subunit alpha-2 |
UniProt Protein Name: | Neuronal acetylcholine receptor subunit alpha-2 |
Protein Family: | Neuronal acetylcholine receptor |
UniProt Gene Name: | CHRNA2 |
UniProt Entry Name: | ACHA2_HUMAN |
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