Anti-CHRDL1 Antibody (CAB15204)
- SKU:
- CAB15204
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
抗体名: | Anti-CHRDL1 Antibody |
抗体コード: | CAB15204 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 289-458 of human CHRDL1 (NP_001137453.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | HeLa, mouse heart, mouse lung |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 289-458 of human CHRDL1 (NP_001137453.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | CTCN VTKQ ECKK IHCP NRYP CKYP QKID GKCC KVCP GKKA KEEL PGQS FDNK GYFC GEET MPVY ESVF MEDG ETTR KIAL ETER PPQV EVHV WTIR KGIL QHFH IEKI SKRM FEEL PHFK LVTR TTLS QWKI FTEG EAQI SQMC SSRV CRTE LEDL VKVL YLER SEKG HC |
遺伝子ID: | 91851 |
Uniprot: | Q9BU40 |
セルラーロケーション: | Secreted |
計算された分子量: | 43kDa/51kDa/52kDa |
観察された分子量: | 51kDa |
同義語: | CHRDL1, CHL, MGC1, MGCN, NRLN1, VOPT, dA141H5.1 |
バックグラウンド: | This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. |
UniProt Protein Function: | CHRDL1: Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. Defects in CHRDL1 are the cause of megalocornea type 1, X-linked (MGC1). MGC1 is an eye disorder in which the corneal diameter is bilaterally enlarged (greater than 13 mm) without an increase in intraocular pressure. It may also be referred to as anterior megalophthalmos, since the entire anterior segment is larger than normal. Features of megalocornea in addition to a deep anterior chamber include astigmatic refractive errors, atrophy of the iris stroma, miosis secondary to decreased function of the dilator muscle, iridodonesis, and tremulousness, subluxation, or dislocation of the lens. Whereas most affected individuals exhibit normal ocular function, complications include cataract development and glaucoma following lenticular dislocation or subluxation. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: Xq23 Cellular Component: extracellular region Biological Process: BMP signaling pathway; compound eye development; eye development Disease: Megalocornea |
NCBI Summary: | This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009] |
UniProt Code: | Q9BU40 |
NCBI GenInfo Identifier: | 27805644 |
NCBI Gene ID: | 91851 |
NCBI Accession: | Q9BU40.1 |
UniProt Secondary Accession: | Q9BU40,Q539E4, Q9Y3H7, B1AKD0, B4DMP3, D3DUY6, E9PGS5 |
UniProt Related Accession: | Q9BU40 |
Molecular Weight: | 52,026 Da |
NCBI Full Name: | Chordin-like protein 1 |
NCBI Synonym Full Names: | chordin like 1 |
NCBI Official Symbol: | CHRDL1 |
NCBI Official Synonym Symbols: | CHL; MGC1; MGCN; VOPT; NRLN1; dA141H5.1 |
NCBI Protein Information: | chordin-like protein 1 |
UniProt Protein Name: | Chordin-like protein 1 |
UniProt Synonym Protein Names: | Neuralin-1; Neurogenesin-1; Ventroptin |
Protein Family: | Chordin-like protein |
UniProt Gene Name: | CHRDL1 |
UniProt Entry Name: | CRDL1_HUMAN |
View AllClose