Anti-CHD3 Antibody (CAB2221)
- SKU:
- CAB2221
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-CHD3 Antibody |
抗体コード: | CAB2221 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1900-2000 of human CHD3 (NP_001005273.1). |
申し込み: | WB |
推奨希釈: | WB 1:200 - 1:1000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Jurkat, Mouse brain, Rat brain |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1900-2000 of human CHD3 (NP_001005273.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | ERSI LSRL ASKG TEPH PTPA YPPG PYAT PPGY GAAF SAAP VGAL AAAG ANYS QMPA GSFI TAAT NGPP VLVK KEKE MVGA LVSD GLDR KEPR AGEV ICID D |
遺伝子ID: | 1107 |
Uniprot: | Q12873 |
セルラーロケーション: | Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center |
計算された分子量: | 222kDa/226kDa/233kDa |
観察された分子量: | 280kDa |
同義語: | CHD3, Mi-2a, Mi2-ALPHA, ZFH |
バックグラウンド: | This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. |
UniProt Protein Function: | Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. |
NCBI Summary: | This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q12873 |
NCBI GenInfo Identifier: | 88911273 |
NCBI Gene ID: | 1107 |
NCBI Accession: | Q12873.3 |
UniProt Secondary Accession: | Q12873,Q9Y4I0, D3DTQ9, E9PG89, |
UniProt Related Accession: | Q12873 |
Molecular Weight: | 233,037 Da |
NCBI Full Name: | Chromodomain-helicase-DNA-binding protein 3 |
NCBI Synonym Full Names: | chromodomain helicase DNA binding protein 3 |
NCBI Official Symbol: | CHD3 |
NCBI Official Synonym Symbols: | ZFH; Mi-2a; Mi2-ALPHA |
NCBI Protein Information: | chromodomain-helicase-DNA-binding protein 3 |
UniProt Protein Name: | Chromodomain-helicase-DNA-binding protein 3 |
UniProt Synonym Protein Names: | ATP-dependent helicase CHD3; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; Zinc finger helicase; hZFH |
Protein Family: | CHD3-type chromatin-remodeling factor |
UniProt Gene Name: | CHD3 |
UniProt Entry Name: | CHD3_HUMAN |
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