Anti-CBP80 Antibody (CAB13939)
- SKU:
- CAB13939
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
抗体名: | Anti-CBP80 Antibody |
抗体コード: | CAB13939 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | A synthetic peptide of human CBP80 |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: | NIH/3T3, Mouse testis, Mouse brain |
免疫原: | A synthetic peptide of human CBP80 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 4686 |
Uniprot: | Q09161 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 91kDa |
観察された分子量: | 100KDa |
同義語: | NCBP1, CBP80, NCBP, Sto1 |
バックグラウンド: | The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. |
UniProt Protein Function: | NCBP1: mediates U snRNA export from the nucleus. Binds to 5' capped mRNA. Found in aU snRNA export complex with RNUXA/PHAX, CBP20, CBP80, RAN, XPO1 and m7G-capped RNA. Interaction with RNUXA/PHAX. Heterodimer with NCBP2. Is part of the exon junction complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1, NXF1, UPF3B, UPF2, THOC4 and/or REFBP2. |
UniProt Protein Details: | Protein type:Translation; RNA processing; Spliceosome Chromosomal Location of Human Ortholog: 9q34.1 Cellular Component: cytoplasm; cytosol; mitochondrion; mRNA cap complex; nucleoplasm; nucleus; ribonucleoprotein complex Molecular Function:protein binding; RNA binding; RNA cap binding Biological Process: gene expression; histone mRNA metabolic process; mRNA 3'-end processing; mRNA capping; mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus; nuclear mRNA cis splicing, via U2-type spliceosome; nuclear mRNA splicing, via spliceosome; positive regulation of cell growth; positive regulation of mRNA 3'-end processing; positive regulation of viral transcription; regulation of translational initiation; RNA elongation from RNA polymerase II promoter; RNA splicing; RNA-mediated gene silencing; spliceosomal snRNP biogenesis; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; viral reproduction |
NCBI Summary: | The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q09161 |
NCBI GenInfo Identifier: | 1705654 |
NCBI Gene ID: | 4686 |
NCBI Accession: | Q09161.1 |
UniProt Secondary Accession: | Q09161,Q59G76, Q5T1V0, Q5T7X2, B2R718, |
UniProt Related Accession: | Q09161 |
Molecular Weight: | 91,839 Da |
NCBI Full Name: | Nuclear cap-binding protein subunit 1 |
NCBI Synonym Full Names: | nuclear cap binding protein subunit 1 |
NCBI Official Symbol: | NCBP1 |
NCBI Official Synonym Symbols: | NCBP; Sto1; CBP80 |
NCBI Protein Information: | nuclear cap-binding protein subunit 1 |
UniProt Protein Name: | Nuclear cap-binding protein subunit 1 |
UniProt Synonym Protein Names: | 80 kDa nuclear cap-binding protein; CBP80; NCBP 80 kDa subunit |
Protein Family: | CBP80/20-dependent translation initiation factor |
UniProt Gene Name: | NCBP1 |
UniProt Entry Name: | NCBP1_HUMAN |