Anti-CASC5 Antibody (CAB13108)
- SKU:
- CAB13108
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
抗体名: | Anti-CASC5 Antibody |
抗体コード: | CAB13108 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CASC5 (NP_733468.3). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
反応性: | Human, Rat |
ポジティブサンプル: | HepG2, U-87MG, HeLa, Jurkat |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CASC5 (NP_733468.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MDGV SSEA NEEN DNIE RPVR RRHS SILK PPRS PLQD LRGG NERV QESN ALRN KKNS RRVS FADT IKVF QTES HMKI VRKS EMEG CSAM VPSQ LQLL PPGF KRFS CLSL PETE TGEN LLLI QNKK LEDN YCEI TGMN TLLS APIH TQMQ QKEF SIIE HTRE RKHA NDQT VIFS DENQ MDLT SSHT VMIT KGLL DNPI SEKS TKID TTSF LANL KLHT EDSR MKKE VNFS VDQN TSSE NKID FNDF IKRL KTGK CSAF PDVP DKEN FEIP IYSK EPNS ASST HQMH VSLK EDEN NSNI TRLF |
遺伝子ID: | 57082 |
Uniprot: | Q8NG31 |
セルラーロケーション: | Chromosome, Nucleus, centromere, kinetochore |
計算された分子量: | 195kDa/205kDa/262kDa/265kDa |
観察された分子量: | 300kDa |
同義語: | AF15Q14, CASC5, CT29, D40, MCPH4, PPP1R55, Spc7, hKNL-1, hSpc105, KNL1 |
バックグラウンド: | The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. |
UniProt Protein Function: | Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore. |
NCBI Summary: | The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jan 2013] |
UniProt Code: | Q8NG31 |
NCBI GenInfo Identifier: | 223590239 |
NCBI Gene ID: | 57082 |
NCBI Accession: | Q8NG31.3 |
UniProt Secondary Accession: | Q8NG31,Q8NHE1, Q8WXA6, Q9HCK2, Q9NR92, |
UniProt Related Accession: | Q8NG31 |
Molecular Weight: | 205,826 Da |
NCBI Full Name: | Protein CASC5 |
NCBI Synonym Full Names: | kinetochore scaffold 1 |
NCBI Official Symbol: | KNL1 |
NCBI Official Synonym Symbols: | D40; CT29; Spc7; CASC5; MCPH4; hKNL-1; AF15Q14; PPP1R55; hSpc105 |
NCBI Protein Information: | protein CASC5 |
UniProt Protein Name: | Protein CASC5 |
UniProt Synonym Protein Names: | ALL1-fused gene from chromosome 15q14 protein; AF15q14; Bub-linking kinetochore protein; Blinkin; Cancer susceptibility candidate gene 5 protein; Cancer/testis antigen 29; CT29; Kinetochore-null protein 1; Protein D40/AF15q14 |
Protein Family: | Protein |
UniProt Gene Name: | CASC5 |
UniProt Entry Name: | CASC5_HUMAN |
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