Anti-CAND1 Antibody (CAB14287)
- SKU:
- CAB14287
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-CAND1 Antibody |
抗体コード: | CAB14287 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 750-980 of human CAND1 (NP_060918.2). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa, Mouse brain, Mouse heart, Mouse kidney, Mouse liver, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 750-980 of human CAND1 (NP_060918.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | GALS AMLD FFQA LVVT GTNN LGYM DLLR MLTG PVYS QSTA LTHK QSYY SIAK CVAA LTRA CPKE GPAV VGQF IQDV KNSR STDS IRLL ALLS LGEV GHHI DLSG QLEL KSVI LEAF SSPS EEVK SAAS YALG SISV GNLP EYLP FVLQ EITS QPKR QYLL LHSL KEII SSAS VVGL KPYV ENIW ALLL KHCE CAEE GTRN VVAE CLGK LTLI DPET LLPR LKGY LISG SSY |
遺伝子ID: | 55832 |
Uniprot: | Q86VP6 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 45kDa/117kDa/136kDa |
観察された分子量: | 136kDa |
同義語: | CAND1, TIP120, TIP120A |
バックグラウンド: | This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. |
NCBI Summary: | This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016] |
UniProt Code: | Q86VP6 |
NCBI GenInfo Identifier: | 67460541 |
NCBI Gene ID: | 55832 |
NCBI Accession: | Q86VP6.2 |
UniProt Secondary Accession: | Q86VP6,O94918, Q6PIY4, Q8NDJ4, Q96JZ9, Q96T19, Q9BTC4 Q9H0G2, Q9P0H7, Q9UF85, B2RAU3, |
UniProt Related Accession: | Q86VP6 |
Molecular Weight: | 136 kDa |
NCBI Full Name: | Cullin-associated NEDD8-dissociated protein 1 |
NCBI Synonym Full Names: | cullin associated and neddylation dissociated 1 |
NCBI Official Symbol: | CAND1 |
NCBI Official Synonym Symbols: | TIP120; TIP120A |
NCBI Protein Information: | cullin-associated NEDD8-dissociated protein 1 |
UniProt Protein Name: | Cullin-associated NEDD8-dissociated protein 1 |
UniProt Synonym Protein Names: | Cullin-associated and neddylation-dissociated protein 1; TBP-interacting protein of 120 kDa A; TBP-interacting protein 120A; p120 CAND1 |
UniProt Gene Name: | CAND1 |
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