Anti-C4BPB Antibody (CAB6362)
- SKU:
- CAB6362
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
抗体名: | Anti-C4BPB Antibody |
抗体コード: | CAB6362 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-251 of human C4BPB (NP_001017364.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HT-29, HepG2, Mouse testis, Rat testis |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-251 of human C4BPB (NP_001017364.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | SDEH CPEL PPVD NSIF VAKE VEGQ ILGT YVCI KGYH LVGK KTLF CNAS KEWD NTTT ECRL GHCP DPVL VNGE FSSS GPVN VSDK ITFM CNDH YILK GSNR SQCL EDHT WAPP FPIC KSRD CDPP GNPV HGYF EGNN FTLG STIS YYCE DRYY LVGV QEQQ CVDG EWSS ALPV CKLI QEAP KPEC EKAL LAFQ ESKN LCEA MENF MQQL KESG MTME ELKY SLEL KKAE LKAK LL |
遺伝子ID: | 725 |
Uniprot: | P20851 |
セルラーロケーション: | Secreted |
計算された分子量: | 28kDa |
観察された分子量: | 54kDa |
同義語: | C4BPB, C4BP |
バックグラウンド: | This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. |
UniProt Protein Function: | C4BPB: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 1q32 Cellular Component: extracellular space; plasma membrane Molecular Function:protein binding Biological Process: blood coagulation; negative regulation of complement activation, classical pathway; positive regulation of protein catabolic process; regulation of complement activation |
NCBI Summary: | This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008] |
UniProt Code: | P20851 |
NCBI GenInfo Identifier: | 115213 |
NCBI Gene ID: | 725 |
NCBI Accession: | P20851.1 |
UniProt Secondary Accession: | P20851,Q5VVR0, Q9BS25, A5JYP8, D3DT81, |
UniProt Related Accession: | P20851 |
Molecular Weight: | 28,286 Da |
NCBI Full Name: | C4b-binding protein beta chain |
NCBI Synonym Full Names: | complement component 4 binding protein beta |
NCBI Official Symbol: | C4BPB |
NCBI Official Synonym Symbols: | C4BP |
NCBI Protein Information: | C4b-binding protein beta chain |
UniProt Protein Name: | C4b-binding protein beta chain |
Protein Family: | C4b-binding protein |
UniProt Gene Name: | C4BPB |
UniProt Entry Name: | C4BPB_HUMAN |
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