Anti-BPGM Antibody (CAB7880)
- SKU:
- CAB7880
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-BPGM Antibody |
抗体コード: | CAB7880 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-259 of human BPGM (NP_001715.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | 293T, Jurkat, HeLa, Mouse liver, Mouse spleen, Mouse testis, Mouse skeletal muscle, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-259 of human BPGM (NP_001715.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSKY KLIM LRHG EGAW NKEN RFCS WVDQ KLNS EGME EARN CGKQ LKAL NFEF DLVF TSVL NRSI HTAW LILE ELGQ EWVP VESS WRLN ERHY GALI GLNR EQMA LNHG EEQV RLWR RSYN VTPP PIEE SHPY YQEI YNDR RYKV CDVP LDQL PRSE SLKD VLER LLPY WNER IAPE VLRG KTIL ISAH GNSS RALL KHLE GISD EDII NITL PTGV PILL ELDE NLRA VGPH QFLG DQEA IQAA IKKV EDQG KVKQ AKK |
遺伝子ID: | 669 |
Uniprot: | P07738 |
セルラーロケーション: | |
計算された分子量: | 30kDa |
観察された分子量: | 30kDa |
同義語: | BPGM, DPGM |
バックグラウンド: | 2, 3-diphosphoglycerate (2, 3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2, 3-DPG synthesis via its synthetase activity, and 2, 3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
UniProt Protein Function: | BPGM: Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities. Defects in BPGM are the cause of bisphosphoglycerate mutase deficiency (BPGMD). A disease characterized by hemolytic anemia, splenomegaly, cholelithiasis and cholecystitis. Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. |
UniProt Protein Details: | Protein type:EC 5.4.2.4; EC 3.1.3.13; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Phosphatase (non-protein); EC 5.4.2.11; Isomerase Chromosomal Location of Human Ortholog: 7q33 Molecular Function:phosphoglycerate mutase activity; bisphosphoglycerate mutase activity; bisphosphoglycerate phosphatase activity Biological Process: erythrocyte development; glycolysis; dephosphorylation; carbohydrate metabolic process; respiratory gaseous exchange Disease: Bisphosphoglycerate Mutase Deficiency |
NCBI Summary: | 2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009] |
UniProt Code: | P07738 |
NCBI GenInfo Identifier: | 130350 |
NCBI Gene ID: | 669 |
NCBI Accession: | P07738.2 |
UniProt Related Accession: | P07738 |
Molecular Weight: | 30kDa |
NCBI Full Name: | Bisphosphoglycerate mutase |
NCBI Synonym Full Names: | bisphosphoglycerate mutase |
NCBI Official Symbol: | BPGM |
NCBI Official Synonym Symbols: | DPGM; ECYT8 |
NCBI Protein Information: | bisphosphoglycerate mutase |
UniProt Protein Name: | Bisphosphoglycerate mutase |
UniProt Synonym Protein Names: | 2,3-bisphosphoglycerate mutase, erythrocyte; 2,3-bisphosphoglycerate synthase (EC:3.1.3.13, EC:5.4.2.11); 2,3-diphosphoglycerate mutase; DPGM; BPG-dependent PGAM |
Protein Family: | Bisphosphoglycerate mutase |
UniProt Gene Name: | BPGM |
UniProt Entry Name: | PMGE_HUMAN |
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