Anti-BFSP2 Antibody (CAB13055)
- SKU:
- CAB13055
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-BFSP2 Antibody |
抗体コード: | CAB13055 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 116-415 of human BFSP2 (NP_003562.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse |
ポジティブサンプル: | Mouse eye |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 116-415 of human BFSP2 (NP_003562.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | VEYM AKVH ALEQ VSQE LETQ LRMH LESK ATRS GNWG ALRA SWAS SCQQ VGEA VLEN ARLM LQTE TIQA GADD FKER YENE QPFR KAAE EEIN SLYK VIDE ANLT KMDL ESQI ESLK EELG SLSR NYEE DVKL LHKQ LAGC ELEQ MDAP IGTG LDDI LETI RIQW ERDV EKNR VEAG ALLQ AKQQ AEVA HMSQ TQEE KLAA ALRV ELHN TSCQ VQSL QAET ESLR ALKR GLEN TLHD AKHW HDME LQNL GAVV GRLE AELR EIRA EAEQ QQQE RAHL LARK CQLQ KDVA SYHA LLDR EESG |
遺伝子ID: | 8419 |
Uniprot: | Q13515 |
セルラーロケーション: | Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, cell cortex, cytoskeleton |
計算された分子量: | 45kDa |
観察された分子量: | 46kDa |
同義語: | BFSP2, CP47, CP49, CTRCT12, LIFL-L, PHAKOSIN, phakinin |
バックグラウンド: | More than 99% of the vertebrate ocular lens is comprised of terminally differentiated lens fiber cells. Two lens-specific intermediate filament-like proteins, the protein product of this gene (phakinin), and filensin, are expressed only after fiber cell differentiation has begun. Both proteins are found in a structurally unique cytoskeletal element that is referred to as the beaded filament (BF). Mutations in this gene have been associated with juvenile-onset, progressive cataracts and Dowling-Meara epidermolysis bullosa simplex. |
UniProt Protein Function: | BFSP2: Involved in stabilization of lens fiber cell cytoskeleton. Defects in BFSP2 are the cause of cataract autosomal dominant multiple types 1 (ADC-MT1). Cataract is an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. The opacities can be nuclear, sutural, stellate cortical, lamellar, cortical, nuclear embryonic, Y-sutural, punctate cortical, congenital or with juvenile- and adult-onset. Belongs to the intermediate filament family. |
UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 3q22.1 Cellular Component: cytoplasm; plasma membrane Molecular Function:protein binding; structural constituent of cytoskeleton Disease: Cataract 12, Multiple Types |
NCBI Summary: | More than 99% of the vertebrate ocular lens is comprised of terminally differentiated lens fiber cells. Two lens-specific intermediate filament-like proteins, the protein product of this gene (phakinin), and filensin, are expressed only after fiber cell differentiation has begun. Both proteins are found in a structurally unique cytoskeletal element that is referred to as the beaded filament (BF). Mutations in this gene have been associated with juvenile-onset, progressive cataracts and Dowling-Meara epidermolysis bullosa simplex. [provided by RefSeq, Jun 2009] |
UniProt Code: | Q13515 |
NCBI GenInfo Identifier: | 109731294 |
NCBI Gene ID: | 8419 |
NCBI Accession: | BC113518 |
UniProt Secondary Accession: | Q13515,Q14D32, Q9HBW5, |
UniProt Related Accession: | Q13515 |
Molecular Weight: | 45,880 Da |
NCBI Full Name: | Homo sapiens beaded filament structural protein 2, phakinin, mRNA |
NCBI Synonym Full Names: | beaded filament structural protein 2 |
NCBI Official Symbol: | BFSP2 |
NCBI Official Synonym Symbols: | CP47; CP49; LIFL-L; CTRCT12; PHAKOSIN |
NCBI Protein Information: | phakinin |
UniProt Protein Name: | Phakinin |
UniProt Synonym Protein Names: | 49 kDa cytoskeletal protein; Beaded filament structural protein 2; Lens fiber cell beaded filament protein CP 47; CP47; Lens fiber cell beaded filament protein CP 49; CP49; Lens intermediate filament-like light; LIFL-L |
Protein Family: | Phakinin |
UniProt Gene Name: | BFSP2 |
UniProt Entry Name: | BFSP2_HUMAN |
View AllClose