Anti-BCMO1 Antibody (CAB15848)
- SKU:
- CAB15848
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-BCMO1 Antibody |
抗体コード: | CAB15848 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 268-547 of human BCMO1 (NP_059125.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HT-29, 293T, LO2, Mouse liver, Mouse testis |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 268-547 of human BCMO1 (NP_059125.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSWA SCLA FHRE EKTY IHII DQRT RQPV QTKF YTDA MVVF HHVN AYEE DGCI VFDV IAYE DNSL YQLF YLAN LNQD FKEN SRLT SVPT LRRF AVPL HVDK NAEV GTNL IKVA STTA TALK EEDG QVYC QPEF LYEG LELP RVNY AHNG KQYR YVFA TGVQ WSPI PTKI IKYD ILTK SSLK WRED DCWP AEPL FVPA PGAK DEDD GVIL SAIV STDP QKLP FLLI LDAK SFTE LARA SVDV DMHM DLHG LFIT DMDW DTKK QAAS EEQR DRAS DCHG APLT |
遺伝子ID: | 53630 |
Uniprot: | Q9HAY6 |
セルラーロケーション: | |
計算された分子量: | 62kDa |
観察された分子量: | 75kDa |
同義語: | BCO1, BCDO, BCDO1, BCMO, BCMO1, BCO |
バックグラウンド: | Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta, beta-carotene into two retinal molecules. |
UniProt Protein Function: | BCMO1: Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed. Defects in BCMO1 are the cause of autosomal dominant hypercarotenemia and vitamin A deficiency (ADHVAD). Vitamin A is essential for normal embryonic development as well as normal physiological functions in children and adults. Hypercarotenemia is characterized by an excess carotene in the serum, but unlike excess vitamin A, carotene is non-toxic. So far, only a few cases of excess vitamin A have been reported. Individuals were thought to be vitamin A deficient due to an impairment in the conversion of carotenoids to retinal in the intestine. Belongs to the carotenoid oxygenase family. |
UniProt Protein Details: | Protein type:Cofactor and Vitamin Metabolism - retinol; Oxidoreductase; EC 1.14.99.36 Chromosomal Location of Human Ortholog: 16q23.2 Cellular Component: cytosol Molecular Function:beta-carotene 15,15'-monooxygenase activity; metal ion binding Biological Process: fat-soluble vitamin metabolic process; phototransduction, visible light; retinal metabolic process; retinoid metabolic process; retinol metabolic process; vitamin A biosynthetic process; vitamin metabolic process Disease: Hypercarotenemia And Vitamin A Deficiency, Autosomal Dominant |
NCBI Summary: | Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9HAY6 |
NCBI GenInfo Identifier: | 74027270 |
NCBI Gene ID: | 53630 |
NCBI Accession: | NP_059125.2 |
UniProt Secondary Accession: | Q9HAY6,Q9NVH5, A0AV48, A0AV50, |
UniProt Related Accession: | Q9HAY6 |
Molecular Weight: | 62,637 Da |
NCBI Full Name: | beta,beta-carotene 15,15'-dioxygenase |
NCBI Synonym Full Names: | beta-carotene oxygenase 1 |
NCBI Official Symbol: | BCO1 |
NCBI Official Synonym Symbols: | BCO; BCDO; BCMO; BCDO1; BCMO1 |
NCBI Protein Information: | beta,beta-carotene 15,15'-dioxygenase |
UniProt Protein Name: | Beta,beta-carotene 15,15'-dioxygenase |
UniProt Synonym Protein Names: | Beta-carotene dioxygenase 1; Beta-carotene oxygenase 1 |
Protein Family: | Beta,beta-carotene 15,15'-dioxygenase |
UniProt Gene Name: | BCO1 |
UniProt Entry Name: | BCDO1_HUMAN |
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