Anti-ATIC Antibody (CAB5559)
- SKU:
- CAB5559
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
抗体名: | Anti-ATIC Antibody |
抗体コード: | CAB5559 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ATIC (NP_004035.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | MCF7, SW480, NCI-H460, HepG2, SW620, HT-29, K-562 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ATIC (NP_004035.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAPG QLAL FSVS DKTG LVEF ARNL TALG LNLV ASGG TAKA LRDA GLAV RDVS ELTG FPEM LGGR VKTL HPAV HAGI LARN IPED NADM ARLD FNLI RVVA CNLY PFVK TVAS PGVT VEEA VEQI DIGG VTLL RAAA KNHA RVTV VCEP EDYV VVST EMQS SESK DTSL ETRR QLAL KAFT HTAQ YDEA ISDY FRKQ YSKG VSQM PLRY GMNP HQTP AQLY TLQP KLPI TVLN GAPG FINL CDAL NAWQ LVKE LKEA LGIP AAAS FKHV SPAG AAVG IPLS EDEA KVCM VYDL YKTL TPIS |
遺伝子ID: | 471 |
Uniprot: | P31939 |
セルラーロケーション: | |
計算された分子量: | 64kDa |
観察された分子量: | 62kDa |
同義語: | ATIC, AICAR, AICARFT, HEL-S-70p, IMPCHASE, PURH |
バックグラウンド: | This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. |
UniProt Protein Function: | ATIC: Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. Defects in ATIC are the cause of AICAR transformylase/IMP cyclohydrolase deficiency (AICAR). A neurologically devastating inborn error of purine biosynthesis. Patients excrete massive amounts of AICA-riboside in the urine and accumulate AICA- ribotide and its derivatives in erythrocytes and fibroblasts. AICAR causes profound mental retardation, epilepsy, dysmorphic features and congenital blindness. Belongs to the PurH family. |
UniProt Protein Details: | Protein type:Hydrolase; Nucleotide Metabolism - purine; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 3.5.4.10; Methyltransferase; EC 2.1.2.3 Chromosomal Location of Human Ortholog: 2q35 Cellular Component: mitochondrion; membrane; cytosol Molecular Function:protein homodimerization activity; IMP cyclohydrolase activity; phosphoribosylaminoimidazolecarboxamide formyltransferase activity Biological Process: purine ribonucleoside monophosphate biosynthetic process; tetrahydrofolate biosynthetic process; organ regeneration; response to inorganic substance; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; dihydrofolate metabolic process; nucleoside metabolic process; cerebellum development; cerebral cortex development; purine base metabolic process; 'de novo' IMP biosynthetic process Disease: Aicar Transformylase/imp Cyclohydrolase Deficiency |
NCBI Summary: | This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009] |
UniProt Code: | P31939 |
NCBI GenInfo Identifier: | 23831360 |
NCBI Gene ID: | 471 |
NCBI Accession: | P31939.3 |
UniProt Secondary Accession: | P31939,Q13856, Q53S28, A8K202, E9PBU3, |
UniProt Related Accession: | P31939 |
Molecular Weight: | 592 |
NCBI Full Name: | Bifunctional purine biosynthesis protein PURH |
NCBI Synonym Full Names: | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
NCBI Official Symbol: | ATIC |
NCBI Official Synonym Symbols: | PURH; AICAR; AICARFT; IMPCHASE; HEL-S-70p |
NCBI Protein Information: | bifunctional purine biosynthesis protein PURH; AICARFT/IMPCHASE; epididymis secretory sperm binding protein Li 70p; AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase |
UniProt Protein Name: | Bifunctional purine biosynthesis protein PURH |
UniProt Synonym Protein Names: | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR transformylase |
UniProt Gene Name: | ATIC |
UniProt Entry Name: | PUR9_HUMAN |