Anti-ASIC3 Antibody (CAB10268)
- SKU:
- CAB10268
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-ASIC3 Antibody |
抗体コード: | CAB10268 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 62-320 of human ASIC3 (NP_064717.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse liver, Rat brain, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 62-320 of human ASIC3 (NP_064717.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | ERVR YYRE FHHQ TALD ERES HRLI FPAV TLCN INPL RRSR LTPN DLHW AGSA LLGL DPAE HAAF LRAL GRPP APPG FMPS PTFD MAQL YARA GHSL DDML LDCR FRGQ PCGP ENFT TIFT RMGK CYTF NSGA DGAE LLTT TRGG MGNG LDIM LDVQ QEEY LPVW RDNE ETPF EVGI RVQI HSQE EPPI IDQL GLGV SPGY QTFV SCQQ QQLS FLPP PWGD CSSA SLNP NYEP EPSD PLGS PSPS PSPP YTLM GCRL ACE |
遺伝子ID: | 9311 |
Uniprot: | Q9UHC3 |
セルラーロケーション: | Cell membrane, Cytoplasm, Multi-pass membrane protein |
計算された分子量: | 44kDa/58kDa/60kDa |
観察された分子量: | 59kDa |
同義語: | ASIC3, ACCN3, DRASIC, SLNAC1, TNaC1 |
バックグラウンド: | This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. |
UniProt Protein Function: | Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. |
NCBI Summary: | This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q9UHC3 |
NCBI GenInfo Identifier: | 82582992 |
NCBI Gene ID: | 9311 |
NCBI Accession: | Q9UHC3.2 |
UniProt Secondary Accession: | Q9UHC3,O60263, O75906, Q59FN9, Q9UER8, Q9UHC4, B2R9V0 |
UniProt Related Accession: | Q9UHC3 |
Molecular Weight: | 59kDa |
NCBI Full Name: | Acid-sensing ion channel 3 |
NCBI Synonym Full Names: | acid sensing ion channel subunit 3 |
NCBI Official Symbol: | ASIC3 |
NCBI Official Synonym Symbols: | ACCN3; TNaC1; DRASIC; SLNAC1 |
NCBI Protein Information: | acid-sensing ion channel 3 |
UniProt Protein Name: | Acid-sensing ion channel 3 |
UniProt Synonym Protein Names: | Amiloride-sensitive cation channel 3; Neuronal amiloride-sensitive cation channel 3; Testis sodium channel 1; hTNaC1 |
Protein Family: | Acid-sensing ion channel |
UniProt Gene Name: | ASIC3 |
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