Anti-ANGPTL3 Antibody (CAB5225)
- SKU:
- CAB5225
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cardiovascular
Description
抗体名: | Anti-ANGPTL3 Antibody |
抗体コード: | CAB5225 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human ANGPTL3 |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HepG2, A375, Mouse lung, Mouse liver, Rat lung, Rat liver |
免疫原: | A synthesized peptide derived from human ANGPTL3 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 27329 |
Uniprot: | Q9Y5C1 |
セルラーロケーション: | |
計算された分子量: | 54kDa |
観察された分子量: | 54KDa |
同義語: | ANG-5, ANGPT5, ANL3, FHBL2 |
バックグラウンド: | This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015] |
UniProt Protein Function: | ANGPTL3: Defects in ANGPTL3 are the cause of familial hypobetalipoproteinemia type 2 (FHBL2); also called combined hypobetalipoproteinemia familial. FHBL2 is a disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Affected individuals present with combined hypolipidemia, consisting of extremely low plasma levels of LDL cholesterol, HDL cholesterol, and triglycerides. |
UniProt Protein Details: | Protein type:Secreted; Cell adhesion; Inhibitor; Motility/polarity/chemotaxis; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1p31.3 Cellular Component: extracellular space; cell surface Molecular Function:integrin binding; enzyme inhibitor activity; phospholipase inhibitor activity; growth factor activity Biological Process: integrin-mediated signaling pathway; cholesterol metabolic process; phospholipid catabolic process; glycerol metabolic process; cell-matrix adhesion; lipid homeostasis; positive regulation of lipid catabolic process; fatty acid metabolic process; signal transduction; sequestering of lipid; positive regulation of angiogenesis; cholesterol homeostasis; acylglycerol homeostasis; phospholipid metabolic process; artery morphogenesis; negative regulation of lipoprotein lipase activity; positive regulation of cell migration; phospholipid homeostasis Disease: Hypobetalipoproteinemia, Familial, 2 |
NCBI Summary: | This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015] |
UniProt Code: | Q9Y5C1 |
NCBI GenInfo Identifier: | 25008126 |
NCBI Gene ID: | 27329 |
NCBI Accession: | Q9Y5C1.1 |
UniProt Related Accession: | Q9Y5C1 |
Molecular Weight: | ~ 54kDa |
NCBI Full Name: | Angiopoietin-related protein 3 |
NCBI Synonym Full Names: | angiopoietin like 3 |
NCBI Official Symbol: | ANGPTL3 |
NCBI Official Synonym Symbols: | ANL3; ANG-5; FHBL2; ANGPT5 |
NCBI Protein Information: | angiopoietin-related protein 3 |
UniProt Protein Name: | Angiopoietin-related protein 3 |
UniProt Synonym Protein Names: | Angiopoietin-5; ANG-5; Angiopoietin-like protein 3 |
Protein Family: | Angiopoietin-related protein |
UniProt Gene Name: | ANGPTL3 |
UniProt Entry Name: | ANGL3_HUMAN |