Anti-ALKBH2 Antibody (CAB6340)
- SKU:
- CAB6340
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-ALKBH2 Antibody |
抗体コード: | CAB6340 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human ALKBH2 (NP_001138847.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | MCF7, HeLa, HepG2 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human ALKBH2 (NP_001138847.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MDRF LVKG AQGG LLRK QEEQ EPTG EEPA VLGG DKES TRKR PRRE APGN GGHS AGPS WRHI RAEG LDCS YTVL FGKA EADE IFQE LEKE VEYF TGAL ARVQ VFGK WHSV PRKQ ATYG DAGL TYTF SGLT LSPK PWIP VLER IRDH VSGV TGQT FNFV LINR YKDG CDHI GEHR DDER ELAP GSPI ASVS FGAC RDFV FRHK DSRG KSPS RRVA VVRL PLAH GSLL MMNH PTNT HWYH SLPV RKKV LAPR VNLT FRKI LLTK K |
遺伝子ID: | 121642 |
Uniprot: | Q6NS38 |
セルラーロケーション: | Nucleus |
計算された分子量: | 17kDa/29kDa |
観察された分子量: | 35kDa |
同義語: | ALKBH2, ABH2 |
バックグラウンド: |
UniProt Protein Function: | ALKBH2: Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1- ethenoadenine (in vitro). Has strong preference for double- stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Belongs to the alkB family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA repair, damage; EC 1.14.11.33; Oxidoreductase; Hydrolase; Demethylase Chromosomal Location of Human Ortholog: 12q24.11 Cellular Component: microtubule cytoskeleton; nucleoplasm; nucleus Molecular Function:ferrous iron binding; DNA-N1-methyladenine dioxygenase activity; DNA demethylase activity Biological Process: DNA dealkylation; DNA repair |
NCBI Summary: | The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q6NS38 |
NCBI GenInfo Identifier: | 74736661 |
NCBI Gene ID: | 121642 |
NCBI Accession: | Q6NS38.1 |
UniProt Related Accession: | Q6NS38 |
Molecular Weight: | |
NCBI Full Name: | DNA oxidative demethylase ALKBH2 |
NCBI Synonym Full Names: | alkB homolog 2, alpha-ketoglutarate dependent dioxygenase |
NCBI Official Symbol: | ALKBH2 |
NCBI Official Synonym Symbols: | ABH2 |
NCBI Protein Information: | DNA oxidative demethylase ALKBH2 |
UniProt Protein Name: | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 |
UniProt Synonym Protein Names: | Alkylated DNA repair protein alkB homolog 2; DNA oxidative demethylase ALKBH2; Oxy DC1 |
Protein Family: | Alkane 1-monooxygenase |
UniProt Gene Name: | ALKBH2 |
UniProt Entry Name: | ALKB2_HUMAN |
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