Anti-ALDH1L1 Antibody (CAB7067)
- SKU:
- CAB7067
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-ALDH1L1 Antibody |
抗体コード: | CAB7067 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ALDH1L1 (NP_036322.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HepG2, MCF7, Jurkat, Mouse liver, Mouse brain, Mouse heart, Mouse kidney, Rat brain, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ALDH1L1 (NP_036322.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MKIA VIGQ SLFG QEVY CHLR KEGH EVVG VFTV PDKD GKAD PLGL EAEK DGVP VFKY SRWR AKGQ ALPD VVAK YQAL GAEL NVLP FCSQ FIPM EIIS APRH GSII YHPS LLPR HRGA SAIN WTLI HGDK KGGF SIFW ADDG LDTG DLLL QKEC EVLP DDTV STLY NRFL FPEG IKGM VQAV RLIA EGKA PRLP QPEE GATY EGIQ KKET AKIN WDQP AEAI HNWI RGND KVPG AWTE ACEQ KLTF FNST LN |
遺伝子ID: | 10840 |
Uniprot: | O75891 |
セルラーロケーション: | Cytoplasm |
計算された分子量: | 55kDa/87kDa/98kDa/99kDa |
観察された分子量: | 120kDa |
同義語: | ALDH1L1, 10-FTHFDH, 10-fTHF, FDH, FTHFD |
バックグラウンド: | The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | ALDH1L1: 2 isoforms of the human protein are produced by alternative splicing |
UniProt Protein Details: | Protein type:Cofactor and Vitamin Metabolism - one carbon pool by folate; Oxidoreductase; EC 1.5.1.6 Chromosomal Location of Human Ortholog: 3q21.3 Cellular Component: mitochondrion Molecular Function:methyltransferase activity; aldehyde dehydrogenase (NAD) activity; formyltetrahydrofolate dehydrogenase activity; hydroxymethyl-, formyl- and related transferase activity; catalytic activity Biological Process: methylation; biosynthetic process; one-carbon compound metabolic process; 10-formyltetrahydrofolate catabolic process |
NCBI Summary: | The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] |
UniProt Code: | O75891 |
NCBI GenInfo Identifier: | 59802911 |
NCBI Gene ID: | 10840 |
NCBI Accession: | O75891.2 |
UniProt Secondary Accession: | O75891,Q68CS1, B4DG36, E9PBX3, |
UniProt Related Accession: | O75891 |
Molecular Weight: | 902 |
NCBI Full Name: | Cytosolic 10-formyltetrahydrofolate dehydrogenase |
NCBI Synonym Full Names: | aldehyde dehydrogenase 1 family, member L1 |
NCBI Official Symbol: | ALDH1L1 |
NCBI Official Synonym Symbols: | FDH; FTHFD; 10-fTHF; 10-FTHFDH |
NCBI Protein Information: | cytosolic 10-formyltetrahydrofolate dehydrogenase; MER57B-ALDH1L1 |
UniProt Protein Name: | Cytosolic 10-formyltetrahydrofolate dehydrogenase |
UniProt Synonym Protein Names: | Aldehyde dehydrogenase family 1 member L1 |
Protein Family: | Cytosolic 10-formyltetrahydrofolate dehydrogenase |
UniProt Gene Name: | ALDH1L1 |
UniProt Entry Name: | AL1L1_HUMAN |
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