Anti-AKAP7 Antibody (CAB11728)
- SKU:
- CAB11728
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-AKAP7 Antibody |
抗体コード: | CAB11728 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-81 of human AKAP7 (NP_004833.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:1000 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse brain, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-81 of human AKAP7 (NP_004833.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MGQL CCFP FSRD EGKI SEKN GGEP DDAE LVRL SKRL VENA VLKA VQQY LEET QNKN KPGE GSSV KTEA ADQN GNDN ENNR K |
遺伝子ID: | 9465 |
Uniprot: | O43687/Q9P0M2 |
セルラーロケーション: | Apical cell membrane, Lateral cell membrane, Lipid-anchor, Lipid-anchor |
計算された分子量: | 8kDa/11kDa/39kDa |
観察された分子量: | 14kDa |
同義語: | AKAP7, AKAP15, AKAP18 |
バックグラウンド: | This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described. |
UniProt Protein Function: | AKAP7 iso1: Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane- associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 6q23.2 Cellular Component: cytosol Molecular Function:protein binding; protein kinase A binding Biological Process: protein localization |
NCBI Summary: | This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Apr 2011] |
UniProt Code: | O43687 |
NCBI GenInfo Identifier: | 25108878 |
NCBI Gene ID: | 9465 |
NCBI Accession: | O43687.4 |
UniProt Secondary Accession: | O43687,Q5TBR9, Q5TBS0, Q9HCZ8, Q9P0G4, A8K2K6, |
UniProt Related Accession: | Q9P0M2,O43687 |
Molecular Weight: | 11kDa |
NCBI Full Name: | A-kinase anchor protein 7 isoforms alpha and beta |
NCBI Synonym Full Names: | A-kinase anchoring protein 7 |
NCBI Official Symbol: | AKAP7 |
NCBI Official Synonym Symbols: | AKAP15; AKAP18 |
NCBI Protein Information: | A-kinase anchor protein 7 isoform gamma; A-kinase anchor protein 7 |
UniProt Protein Name: | A-kinase anchor protein 7 isoforms alpha and beta |
UniProt Synonym Protein Names: | A-kinase anchor protein 18 kDa; AKAP 18; Protein kinase A-anchoring protein 7 isoforms alpha/beta; PRKA7 isoforms alpha/beta |
Protein Family: | A-kinase anchor protein |
UniProt Gene Name: | AKAP7 |
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