Anti-ADCY4 Antibody (CAB10647)
- SKU:
- CAB10647
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
抗体名: | Anti-ADCY4 Antibody |
抗体コード: | CAB10647 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 808-1077 of human ADCY4 (NP_640340.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Rat |
ポジティブサンプル: |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 808-1077 of human ADCY4 (NP_640340.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | RQNE YYCR LDFL WKKK LRQE REET ETME NLTR LLLE NVLP AHVA PQFI GQNR RNED LYHQ SYEC VCVL FASV PDFK EFYS ESNI NHEG LECL RLLN EIIA DFDE LLSK PKFS GVEK IKTI GSTY MAAT GLNA TSGQ DAQQ DAER SCSH LGTM VEFA VALG SKLD VINK HSFN NFRL RVGL NHGP VVAG VIGA QKPQ YDIW GNTV NVAS RMES TGVL GKIQ VTEE TAWA LQSL GYTC YSRG VIKV KGKG QLCT YFLN TDLT RTGP PSAT LG |
遺伝子ID: | 196883 |
Uniprot: | Q8NFM4 |
セルラーロケーション: | Cell membrane, Cytoplasm, Multi-pass membrane protein |
計算された分子量: | 46kDa/119kDa |
観察された分子量: | Refer to Figures |
同義語: | ADCY4, AC4 |
バックグラウンド: | This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. |
UniProt Protein Function: | ADCY4: This is a membrane-bound, calmodulin-insensitive adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. |
UniProt Protein Details: | Protein type:Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family Chromosomal Location of Human Ortholog: 14q12 Cellular Component: cytoplasm; guanylate cyclase complex, soluble; membrane; plasma membrane Molecular Function:adenylate cyclase activity; guanylate cyclase activity; protein binding Biological Process: activation of protein kinase A; adenylate cyclase activation; cAMP biosynthetic process; cGMP biosynthetic process; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; renal water homeostasis; signal transduction |
NCBI Summary: | This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010] |
UniProt Code: | Q8NFM4 |
NCBI GenInfo Identifier: | 25008336 |
NCBI Gene ID: | 196883 |
NCBI Accession: | Q8NFM4.1 |
UniProt Secondary Accession: | Q8NFM4,Q17R40, Q6ZTM6, Q96ML7, B3KV74, D3DS75, |
UniProt Related Accession: | Q8NFM4 |
Molecular Weight: | 120kDa |
NCBI Full Name: | Adenylate cyclase type 4 |
NCBI Synonym Full Names: | adenylate cyclase 4 |
NCBI Official Symbol: | ADCY4 |
NCBI Official Synonym Symbols: | AC4 |
NCBI Protein Information: | adenylate cyclase type 4 |
UniProt Protein Name: | Adenylate cyclase type 4 |
UniProt Synonym Protein Names: | ATP pyrophosphate-lyase 4; Adenylate cyclase type IV; Adenylyl cyclase 4 |
Protein Family: | Adenylate cyclase |
UniProt Gene Name: | ADCY4 |