Anti-ACSL1 Antibody (CAB1000)
- SKU:
- CAB1000
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
抗体名: | Anti-ACSL1 Antibody |
抗体コード: | CAB1000 |
抗体サイズ: | 100µL |
申し込み: | WB IHC IF IP |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide of human ACSL1 |
申し込み: | WB IHC IF IP |
推奨希釈: | WB 1:200 - 1:1000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HepG2 |
免疫原: | A synthetic peptide of human ACSL1 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 2180 |
Uniprot: | P33121 |
セルラーロケーション: | Endoplasmic reticulum membrane, Microsome membrane, Mitochondrion outer membrane, Peroxisome membrane, Single-pass type III membrane protein |
計算された分子量: | 76kDa/77kDa |
観察された分子量: | 78kDa |
同義語: | ACS1, FACL1, FACL2, LACS, LACS1, LACS2, ACSL1 |
バックグラウンド: | The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | ACSL1: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Lipid Metabolism - fatty acid; Ligase; Membrane protein, integral; EC 6.2.1.3 Chromosomal Location of Human Ortholog: 4q35.1 Cellular Component: peroxisomal membrane; mitochondrial outer membrane; endoplasmic reticulum membrane; mitochondrion; membrane; plasma membrane; integral to membrane Molecular Function:ATP binding; long-chain-fatty-acid-CoA ligase activity Biological Process: response to drug; response to oleate; unsaturated fatty acid metabolic process; lipid biosynthetic process; linoleic acid metabolic process; adiponectin-mediated signaling pathway; triacylglycerol biosynthetic process; cellular lipid metabolic process; long-chain fatty acid metabolic process; response to organic cyclic substance; response to nutrient; xenobiotic catabolic process |
NCBI Summary: | The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] |
UniProt Code: | P33121 |
NCBI GenInfo Identifier: | 417241 |
NCBI Gene ID: | 2180 |
NCBI Accession: | P33121.1 |
UniProt Related Accession: | P33121 |
Molecular Weight: | |
NCBI Full Name: | Long-chain-fatty-acid--CoA ligase 1 |
NCBI Synonym Full Names: | acyl-CoA synthetase long chain family member 1 |
NCBI Official Symbol: | ACSL1 |
NCBI Official Synonym Symbols: | ACS1; LACS; FACL1; FACL2; LACS1; LACS2 |
NCBI Protein Information: | long-chain-fatty-acid--CoA ligase 1 |
UniProt Protein Name: | Long-chain-fatty-acid--CoA ligase 1 |
UniProt Synonym Protein Names: | Acyl-CoA synthetase 1; ACS1; Long-chain acyl-CoA synthetase 1; LACS 1; Long-chain acyl-CoA synthetase 2; LACS 2; Long-chain fatty acid-CoA ligase 2; Palmitoyl-CoA ligase 1; Palmitoyl-CoA ligase 2 |
Protein Family: | Long-chain-fatty-acid--CoA ligase |
UniProt Gene Name: | ACSL1 |
UniProt Entry Name: | ACSL1_HUMAN |