Anti-ABCC8 Antibody (CAB8456)
- SKU:
- CAB8456
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
抗体名: | Anti-ABCC8 Antibody |
抗体コード: | CAB8456 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 700-1000 of human ABCC8 (NP_000343.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse |
ポジティブサンプル: | Mouse pancreas |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 700-1000 of human ABCC8 (NP_000343.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | TIRI PRGQ LTMI VGQV GCGK SSLL LAAL GEMQ KVSG AVFW SSLP DSEI GEDP SPER ETAT DLDI RKRG PVAY ASQK PWLL NATV EENI IFES PFNK QRYK MVIE ACSL QPDI DILP HGDQ TQIG ERGI NLSG GQRQ RISV ARAL YQHA NVVF LDDP FSAL DIHL SDHL MQAG ILEL LRDD KRTV VLVT HKLQ YLPH ADWI IAMK DGTI QREG TLKD FQRS ECQL FEHW KTLM NRQD QELE KETV TERK ATEP PQGL SRAM SSRD GLLQ DEEE EEEE AAES EEDD NLSS MLHQ RAEI PWRA C |
遺伝子ID: | 6833 |
Uniprot: | Q09428 |
セルラーロケーション: | Membrane, Multi-pass membrane protein |
計算された分子量: | 5kDa/176kDa/177kDa |
観察された分子量: | 177kDa |
同義語: | ABCC8, ABC36, HHF1, HI, HRINS, MRP8, PHHI, SUR, SUR1, SUR1delta2, TNDM2 |
バックグラウンド: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. |
UniProt Protein Function: | ABCC8: a multi-pass membrane protein subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. Associates with Kir6.2. Defects in ABCC8 are a cause of persistent hyperinsulinemic hypoglycemia of infancy (PHHI) [MIM:601820, 256450], and may contribute to non-insulin-dependent diabetes mellitus (NIDDM) in Northern European Caucasians. Two alternatively spliced human isoforms have been described. |
UniProt Protein Details: | Protein type:Transporter, ABC family; Membrane protein, integral; Membrane protein, multi-pass; Transporter Chromosomal Location of Human Ortholog: 11p15.1 Cellular Component: voltage-gated potassium channel complex; plasma membrane Molecular Function:ATPase activity, coupled to transmembrane movement of substances; sulfonylurea receptor activity; potassium ion transmembrane transporter activity; ATP binding Biological Process: synaptic transmission; carbohydrate metabolic process; energy reserve metabolic process; signal transduction; regulation of insulin secretion; transmembrane transport; potassium ion transport Disease: Hyperinsulinemic Hypoglycemia, Familial, 1; Diabetes Mellitus, Transient Neonatal, 2; Diabetes Mellitus, Permanent Neonatal; Hypoglycemia, Leucine-induced; Diabetes Mellitus, Noninsulin-dependent |
NCBI Summary: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013] |
UniProt Code: | Q09428 |
NCBI GenInfo Identifier: | 311033501 |
NCBI Gene ID: | 6833 |
NCBI Accession: | Q09428.6 |
UniProt Secondary Accession: | Q09428,O75948, Q16583, A6NMX8, E3UYX6, |
UniProt Related Accession: | Q09428 |
Molecular Weight: | 5,468 Da |
NCBI Full Name: | ATP-binding cassette sub-family C member 8 |
NCBI Synonym Full Names: | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 |
NCBI Official Symbol: | ABCC8 |
NCBI Official Synonym Symbols: | HI; SUR; HHF1; MRP8; PHHI; SUR1; ABC36; HRINS; TNDM2; SUR1delta2 |
NCBI Protein Information: | ATP-binding cassette sub-family C member 8; sulfonylurea receptor 1; sulfonylurea receptor (hyperinsulinemia); ATP-binding cassette transporter sub-family C member 8 |
UniProt Protein Name: | ATP-binding cassette sub-family C member 8 |
UniProt Synonym Protein Names: | Sulfonylurea receptor 1 |
Protein Family: | ABC transporter C family |
UniProt Gene Name: | ABCC8 |
UniProt Entry Name: | ABCC8_HUMAN |