ALCAM Antibody, HRP conjugated (PACO52079)
- SKU:
- PACO52079
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | ALCAM Antibody, HRP conjugated (PACO52079) |
抗体コード: | PACO52079 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human CD166 antigen protein (28-516AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6. Contributes to the formation and maturation of the immunological synapse via its interactions with CD6. Mediates homotypic interactions with cells that express ALCAM. Required for normal hematopoietic stem cell engraftment in the bone marrow. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity). |
シノニム: | CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166), ALCAM, MEMD |
UniProt Protein Function: | ALCAM: Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 3q13.1 Cellular Component: focal adhesion; cell soma; axon; integral to membrane; external side of plasma membrane Molecular Function:protein binding; receptor binding Biological Process: axon guidance; motor axon guidance; signal transduction; cell adhesion |
NCBI Summary: | This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011] |
UniProt Code: | Q13740 |
NCBI GenInfo Identifier: | 118572629 |
NCBI Gene ID: | 214 |
NCBI Accession: | Q13740.2 |
UniProt Secondary Accession: | Q13740,O60892, Q1HGM8, Q1HGM9, Q6PEY4, Q6ZS95, B2RNS3 B4DTU0, |
UniProt Related Accession: | Q13740 |
Molecular Weight: | 33,878 Da |
NCBI Full Name: | CD166 antigen |
NCBI Synonym Full Names: | activated leukocyte cell adhesion molecule |
NCBI Official Symbol: | ALCAM |
NCBI Official Synonym Symbols: | MEMD; CD166 |
NCBI Protein Information: | CD166 antigen |
UniProt Protein Name: | CD166 antigen |
UniProt Synonym Protein Names: | Activated leukocyte cell adhesion molecule; CD_antigen: CD166 |
Protein Family: | CD166 antigen |
UniProt Gene Name: | ALCAM |
UniProt Entry Name: | CD166_HUMAN |