UniProt Protein Function: | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. |
NCBI Summary: | Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008] |
UniProt Code: | P35348 |
NCBI GenInfo Identifier: | 1168246 |
NCBI Gene ID: | 148 |
NCBI Accession: | P35348.2 |
UniProt Secondary Accession: | P35348,O60451, Q13675, Q13729, A8K0I3, B0ZBD1, B0ZBD2 B0ZBD4, B0ZBD5, B0ZBD6, B0ZBD8, B0ZBD9, |
UniProt Related Accession: | P35348 |
Molecular Weight: | 40,638 Da |
NCBI Full Name: | Alpha-1A adrenergic receptor |
NCBI Synonym Full Names: | adrenoceptor alpha 1A |
NCBI Official Symbol: | ADRA1A |
NCBI Official Synonym Symbols: | ADRA1C; ADRA1L1; ALPHA1AAR |
NCBI Protein Information: | alpha-1A adrenergic receptor |
UniProt Protein Name: | Alpha-1A adrenergic receptor |
UniProt Synonym Protein Names: | Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c |
Protein Family: | Alpha-1A adrenergic receptor |
UniProt Gene Name: | ADRA1A |
UniProt Entry Name: | ADA1A_HUMAN |