ACVR1C Antibody (PACO15276)
- SKU:
- PACO15276
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | ACVR1C Antibody (PACO15276) |
抗体コード: | PACO15276 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, IHC:1:15-1:50 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human ACVR1C |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15276(ACVR1C Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]). |
シノニム: | activin A receptor, type IC |
UniProt Protein Function: | ALK7: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; Membrane protein, integral; Protein kinase, TKL; TKL group; STKR family; Type1 subfamily Chromosomal Location of Human Ortholog: 2q24.1 Cellular Component: plasma membrane; activin receptor complex Molecular Function:transforming growth factor beta receptor activity; activin receptor activity, type I; metal ion binding; growth factor binding; ATP binding; receptor signaling protein serine/threonine kinase activity Biological Process: response to dietary excess; sequestering of lipid; apoptotic nuclear changes; response to glucose stimulus; positive regulation of caspase activity; cell differentiation; protein amino acid phosphorylation; negative regulation of insulin secretion; response to insulin stimulus |
NCBI Summary: | ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q8NER5 |
NCBI GenInfo Identifier: | 74762565 |
NCBI Gene ID: | 130399 |
NCBI Accession: | Q8NER5.1 |
UniProt Secondary Accession: | Q8NER5,Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2, |
UniProt Related Accession: | Q8NER5 |
Molecular Weight: | Calculated MW: 37kDa/46kDa/49kDa/54kDaObserved MW: 60kDa |
NCBI Full Name: | Activin receptor type-1C |
NCBI Synonym Full Names: | activin A receptor, type IC |
NCBI Official Symbol: | ACVR1C |
NCBI Official Synonym Symbols: | ALK7; ACVRLK7 |
NCBI Protein Information: | activin receptor type-1C; ALK-7; ACVR1C; ACTR-IC; activin receptor type IC; activin receptor-like kinase 7 |
UniProt Protein Name: | Activin receptor type-1C |
UniProt Synonym Protein Names: | Activin receptor type IC; ACTR-IC; Activin receptor-like kinase 7; ALK-7 |
Protein Family: | Activin receptor |
UniProt Gene Name: | ACVR1C |
UniProt Entry Name: | ACV1C_HUMAN |