ZMYND11 Antibody (PACO52374)
- SKU:
- PACO52374
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ZMYND11 Antibody (PACO52374) |
抗体コード: | PACO52374 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Zinc finger MYND domain-containing protein 11 protein (363-513AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: NIH/3T3 whole cell lysate. All lanes: ZMYND11 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 71, 65, 67, 61 kDa. Observed band size: 71 kDa. | |
Immunofluorescent analysis of A549 cells using PACO52374 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. |
シノニム: | Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69), ZMYND11, BRAM1 BS69 |
UniProt Protein Function: | ZMYND11: Corepressor of transcription (Probable). |
UniProt Protein Details: | Protein type:Tumor suppressor; DNA-binding; Transcription regulation Chromosomal Location of Human Ortholog: 10p14 Cellular Component: nucleoplasm; chromosome; nucleus Molecular Function:protein binding; DNA binding; zinc ion binding; transcription corepressor activity; methylated histone residue binding Biological Process: cell proliferation; negative regulation of JNK cascade; viral reproduction; transcription, DNA-dependent; chromatin modification; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription from RNA polymerase II promoter; cell cycle Disease: Mental Retardation, Autosomal Dominant 30 |
NCBI Summary: | The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q15326 |
NCBI GenInfo Identifier: | 425906058 |
NCBI Gene ID: | 10771 |
NCBI Accession: | Q15326.2 |
UniProt Secondary Accession: | Q15326,Q2LD45, Q2LD46, Q2LD47, Q2LD48, Q5VUI1, Q8N4B3 B2R6G8, B7Z293, F6UH50, |
UniProt Related Accession: | Q15326 |
Molecular Weight: | 562 |
NCBI Full Name: | Zinc finger MYND domain-containing protein 11 |
NCBI Synonym Full Names: | zinc finger, MYND-type containing 11 |
NCBI Official Symbol: | ZMYND11 |
NCBI Official Synonym Symbols: | BS69; BRAM1; MRD30 |
NCBI Protein Information: | zinc finger MYND domain-containing protein 11; adenovirus 5 E1A-binding protein; bone morphogenetic protein receptor-associated molecule 1 |
UniProt Protein Name: | Zinc finger MYND domain-containing protein 11 |
UniProt Synonym Protein Names: | Adenovirus 5 E1A-binding protein; Bone morphogenetic protein receptor-associated molecule 1; Protein BS69 |
Protein Family: | Zinc finger MYND domain-containing protein |
UniProt Gene Name: | ZMYND11 |
UniProt Entry Name: | ZMY11_HUMAN |