ZC3H12A Antibody, Biotin conjugated (PACO36217)
- SKU:
- PACO36217
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | ZC3H12A Antibody, Biotin conjugated (PACO36217) |
抗体コード: | PACO36217 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Endoribonuclease ZC3H12A protein (1-260AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay. Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation. Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity). Self regulates by destabilizing its own mRNA (By similarity). Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner. Plays a role in the inhibition of microRNAs (miRNAs) biogenesis. Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs. Plays also a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity. Affects the overall ubiquitination of cellular proteins (By similarity). Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity). Induces also deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-β (IL1B) stimulation or upon DNA damage. Prevents stress granule (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock and energy deprivation (By similarity). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (By similarity). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis. Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway. Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial proinflammatory cytokine production (By similarity). |
シノニム: | Endoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A), ZC3H12A, MCPIP MCPIP1 |
UniProt Protein Function: | MCPIP1: Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA. Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19. Belongs to the ZC3H12 family. |
UniProt Protein Details: | Protein type:Hydrolase; EC 3.1.-.- Chromosomal Location of Human Ortholog: 1p34.3 Cellular Component: cytoplasm; cytoskeleton; nucleoplasm; nucleus; plasma membrane; rough endoplasmic reticulum Molecular Function:chromatin binding; DNA binding; endoribonuclease activity; exoribonuclease activity; miRNA binding; mRNA 3'-UTR binding; mRNA binding; protein binding; ribonuclease activity; ribosome binding; RNA binding Biological Process: cellular response to glucose starvation; inhibition of NF-kappaB transcription factor; mRNA catabolic process, endonucleolytic cleavage-dependent decay; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of interleukin-1 beta secretion; negative regulation of interleukin-6 production; negative regulation of macrophage activation; negative regulation of NF-kappaB import into nucleus; negative regulation of nitric oxide biosynthetic process; negative regulation of protein amino acid phosphorylation; negative regulation of tumor necrosis factor production; positive regulation of angiogenesis; positive regulation of autophagy; positive regulation of defense response to virus by host; positive regulation of fat cell differentiation; positive regulation of protein import into nucleus; positive regulation of transcription from RNA polymerase II promoter; protein deubiquitination; protein oligomerization; regulation of gene expression |
NCBI Summary: | ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM, Mar 2008] |
UniProt Code: | Q5D1E8 |
NCBI GenInfo Identifier: | 190479827 |
NCBI Gene ID: | 80149 |
NCBI Accession: | Q5D1E8.1 |
UniProt Secondary Accession: | Q5D1E8,Q6I9Z1, Q9H5P1, D3DPT0, |
UniProt Related Accession: | Q5D1E8 |
Molecular Weight: | 65,699 Da |
NCBI Full Name: | Bifunctional endoribonuclease and deubiquitinase ZC3H12A |
NCBI Synonym Full Names: | zinc finger CCCH-type containing 12A |
NCBI Official Symbol: | ZC3H12A |
NCBI Official Synonym Symbols: | MCPIP; MCPIP1; dJ423B22.1 |
NCBI Protein Information: | bifunctional endoribonuclease and deubiquitinase ZC3H12A |
UniProt Protein Name: | Bifunctional endoribonuclease and deubiquitinase ZC3H12A |
UniProt Synonym Protein Names: | Monocyte chemotactic protein-induced protein 1 |
Protein Family: | Ribonuclease |
UniProt Gene Name: | ZC3H12A |
UniProt Entry Name: | ZC12A_HUMAN |