WWOX Antibody, Biotin conjugated (PACO54569)
- SKU:
- PACO54569
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | WWOX Antibody, Biotin conjugated (PACO54569) |
抗体コード: | PACO54569 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human WW domain-containing oxidoreductase protein (1-180AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. |
シノニム: | WW domain-containing oxidoreductase (EC 1.1.1) (Fragile site FRA16D oxidoreductase) (Short chain dehydrogenase/reductase family 41C member 1), WWOX, FOR SDR41C1 WOX1 |
UniProt Protein Function: | WWOX: an enzyme which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). Expressed at high levels in hormonally regulated tissues such as testis, ovary, and prostate. Its SRD domain suggest a role for this gene in steroid metabolism. Shown to be an essential mediator of tumor necrosis factor-alpha-induced apoptosis in the mouse. May play a similar role in the human. May function as a suppressor of tumor growth. Alternative splicing of this gene generates 7 isoforms. |
UniProt Protein Details: | Protein type:Tumor suppressor; Oxidoreductase; Apoptosis; EC 1.1.1.- Chromosomal Location of Human Ortholog: 16q23 Cellular Component: cytoplasm; cytosol; Golgi apparatus; microvillus; mitochondrion; nucleus; plasma membrane Molecular Function:coenzyme binding; cofactor binding; enzyme binding; oxidoreductase activity; protein binding; protein dimerization activity Biological Process: negative regulation of Wnt receptor signaling pathway; osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; skeletal morphogenesis; steroid metabolic process; Wnt receptor signaling pathway Disease: Epileptic Encephalopathy, Early Infantile, 28 |
NCBI Summary: | This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
UniProt Code: | Q9NZC7 |
NCBI GenInfo Identifier: | 74725363 |
NCBI Gene ID: | 51741 |
NCBI Accession: | Q9NZC7.1 |
UniProt Secondary Accession: | Q9NZC7,Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4 Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5, A8K323, |
UniProt Related Accession: | Q9NZC7 |
Molecular Weight: | 23,868 Da |
NCBI Full Name: | WW domain-containing oxidoreductase |
NCBI Synonym Full Names: | WW domain containing oxidoreductase |
NCBI Official Symbol: | WWOX |
NCBI Official Synonym Symbols: | FOR; WOX1; EIEE28; FRA16D; SCAR12; HHCMA56; PRO0128; SDR41C1; D16S432E |
NCBI Protein Information: | WW domain-containing oxidoreductase |
UniProt Protein Name: | WW domain-containing oxidoreductase |
UniProt Synonym Protein Names: | Fragile site FRA16D oxidoreductase; Short chain dehydrogenase/reductase family 41C member 1 |
Protein Family: | WW domain-containing oxidoreductase |
UniProt Gene Name: | WWOX |
UniProt Entry Name: | WWOX_HUMAN |