WEE1 Antibody (PACO49126)
- SKU:
- PACO49126
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | WEE1 Antibody (PACO49126) |
抗体コード: | PACO49126 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Wee1-like protein kinase protein (45-177AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
バックグラウンド: | Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. |
シノニム: | Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase), WEE1 |
UniProt Protein Function: | Wee1: a protein kinase of the WEE family. A nuclear protein which catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. |
UniProt Protein Details: | Protein type:EC 2.7.10.2; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; WEE family Chromosomal Location of Human Ortholog: 11p15.4 Cellular Component: nucleolus; nucleoplasm; nucleus Molecular Function:kinase activity; protein binding; protein-tyrosine kinase activity Biological Process: G2/M transition of mitotic cell cycle; regulation of cell cycle |
NCBI Summary: | This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008] |
UniProt Code: | P30291 |
NCBI GenInfo Identifier: | 1351419 |
NCBI Gene ID: | 7465 |
NCBI Accession: | P30291.2 |
UniProt Secondary Accession: | P30291,B3KVE1, D3DQV0, |
UniProt Related Accession: | P30291 |
Molecular Weight: | 49,072 Da |
NCBI Full Name: | Wee1-like protein kinase |
NCBI Synonym Full Names: | WEE1 G2 checkpoint kinase |
NCBI Official Symbol: | WEE1 |
NCBI Official Synonym Symbols: | WEE1A; WEE1hu |
NCBI Protein Information: | wee1-like protein kinase |
UniProt Protein Name: | Wee1-like protein kinase |
UniProt Synonym Protein Names: | Wee1A kinase |
Protein Family: | Wee1-like protein kinase |
UniProt Gene Name: | WEE1 |
UniProt Entry Name: | WEE1_HUMAN |