USP10 Antibody, Biotin conjugated (PACO55097)
- SKU:
- PACO55097
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | USP10 Antibody, Biotin conjugated (PACO55097) |
抗体コード: | PACO55097 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Ubiquitin carboxyl-terminal hydrolase 10 protein (453-592AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-β (IL1B) stimulation or upon DNA damage. |
シノニム: | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10), USP10, KIAA0190 |
UniProt Protein Function: | USP10: a carboxyl-terminal ubiquitin-processing protease. Ras-GAP SH3 domain-binding protein (G3BP) appears to inhibit its ability to disassemble ubiquitin chains. |
UniProt Protein Details: | Protein type:Protease; Ubiquitin conjugating system; EC 3.4.19.12; RNA-binding; Ubiquitin-specific protease Chromosomal Location of Human Ortholog: 16q24.1 Cellular Component: cytoplasm; early endosome; nucleoplasm; nucleus Molecular Function:cysteine-type endopeptidase activity; p53 binding; protein binding; ubiquitin-specific protease activity Biological Process: bypass DNA synthesis; DNA damage response, signal transduction by p53 class mediator; protein deubiquitination; regulation of autophagy |
NCBI Summary: | Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013] |
UniProt Code: | Q14694 |
NCBI GenInfo Identifier: | 2501458 |
NCBI Gene ID: | 9100 |
NCBI Accession: | Q14694.2 |
UniProt Secondary Accession: | Q14694,Q9BWG7, Q9NSL7, B2RDJ8, B4DS84, |
UniProt Related Accession: | Q14694 |
Molecular Weight: | 87,533 Da |
NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 10 |
NCBI Synonym Full Names: | ubiquitin specific peptidase 10 |
NCBI Official Symbol: | USP10 |
NCBI Official Synonym Symbols: | UBPO |
NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 10 |
UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 10 |
UniProt Synonym Protein Names: | Deubiquitinating enzyme 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10 |
UniProt Gene Name: | USP10 |
UniProt Entry Name: | UBP10_HUMAN |