USF1 Antibody (PACO17391)
- SKU:
- PACO17391
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | USF1 Antibody (PACO17391) |
抗体コード: | PACO17391 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human USF1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17391(USF1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO17391(USF1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. |
シノニム: | upstream transcription factor 1 |
UniProt Protein Function: | USF1: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an homodimer or a heterodimer (USF1/USF2). Interacts with varicella-zoster virus IE62 protein. |
UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 1q22-q23 Cellular Component: nucleoplasm; transcription factor complex; nucleus Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; protein binding; enzyme binding; protein homodimerization activity; sequence-specific DNA binding; protein heterodimerization activity; histone deacetylase binding; double-stranded DNA binding; bHLH transcription factor binding; protein kinase binding Biological Process: transcription from RNA polymerase II promoter; lipid homeostasis; glucose metabolic process; late viral mRNA transcription; glucose homeostasis; regulation of transcription from RNA polymerase II promoter; negative regulation of fibrinolysis; cellular response to insulin stimulus; regulation of transcription from RNA polymerase II promoter by glucose; response to hypoxia; regulation of transcription by carbon catabolites; positive regulation of transcription from RNA polymerase II promoter by glucose; positive regulation of transcription from RNA polymerase II promoter; response to UV Disease: Hyperlipidemia, Combined, 1 |
NCBI Summary: | This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013] |
UniProt Code: | P22415 |
NCBI GenInfo Identifier: | 137170 |
NCBI Gene ID: | 7391 |
NCBI Accession: | P22415.1 |
UniProt Related Accession: | P22415 |
Molecular Weight: | |
NCBI Full Name: | Upstream stimulatory factor 1 |
NCBI Synonym Full Names: | upstream transcription factor 1 |
NCBI Official Symbol: | USF1 |
NCBI Official Synonym Symbols: | UEF; FCHL; MLTF; FCHL1; MLTFI; HYPLIP1; bHLHb11 |
NCBI Protein Information: | upstream stimulatory factor 1 |
UniProt Protein Name: | Upstream stimulatory factor 1 |
UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 11; bHLHb11; Major late transcription factor 1 |
Protein Family: | Upstream stimulatory factor |
UniProt Gene Name: | USF1 |
UniProt Entry Name: | USF1_HUMAN |