UMPS Antibody, HRP conjugated (PACO57205)
- SKU:
- PACO57205
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | UMPS Antibody, HRP conjugated (PACO57205) |
抗体コード: | PACO57205 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Uridine 5'-monophosphate synthase protein (314-444AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | cytoplasm, cytosol, nucleus, orotate phosphoribosyltransferase activity, orotidine-5'-phosphate decarboxylase activity, pyrimidine nucleoside biosynthetic process, UMP biosynthetic process |
シノニム: | Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (EC 4.1.1.23) (OMPdecase)], UMPS |
UniProt Protein Function: | UMPS: Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1). A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 2.4.2.10; Xenobiotic Metabolism - drug metabolism - other enzymes; Transferase; Lyase; EC 4.1.1.23; Nucleotide Metabolism - pyrimidine Chromosomal Location of Human Ortholog: 3q13 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:orotate phosphoribosyltransferase activity; orotidine-5'-phosphate decarboxylase activity Biological Process: pyrimidine nucleoside biosynthetic process; UMP biosynthetic process Disease: Orotic Aciduria |
NCBI Summary: | This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] |
UniProt Code: | P11172 |
NCBI GenInfo Identifier: | 131708 |
NCBI Gene ID: | 7372 |
NCBI Accession: | P11172.1 |
UniProt Secondary Accession: | P11172,O00758, O00759, O00760, Q16862, Q9H3Q2, Q9UG49 B5LY68, B5LY72, |
UniProt Related Accession: | P11172 |
Molecular Weight: | 22,922 Da |
NCBI Full Name: | Uridine 5'-monophosphate synthase |
NCBI Synonym Full Names: | uridine monophosphate synthetase |
NCBI Official Symbol: | UMPS |
NCBI Official Synonym Symbols: | OPRT |
NCBI Protein Information: | uridine 5'-monophosphate synthase |
UniProt Protein Name: | Uridine 5'-monophosphate synthase |
UniProt Synonym Protein Names: | Orotate phosphoribosyltransferase (EC:2.4.2.10); OPRT; OPRTaseOrotidine 5'-phosphate decarboxylase (EC:4.1.1.23); ODCAlternative name(s):OMPdecase |
Protein Family: | Uridine 5'-monophosphate synthase |
UniProt Gene Name: | UMPS |
UniProt Entry Name: | UMPS_HUMAN |