UBA7 Antibody (PACO13014)
- SKU:
- PACO13014
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | UBA7 Antibody (PACO13014) |
抗体コード: | PACO13014 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human |
免疫原: | Human UBA7 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | ubiquitin-like modifier activating enzyme 7;UBA7;D8;MGC12713;UBA1B;UBE1L;UBE2 ; |
UniProt Protein Function: | UBE1L: Activates ubiquitin by first adenylating with ATP its C- terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP. Belongs to the ubiquitin-activating E1 family. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.19 Chromosomal Location of Human Ortholog: 3p21 Cellular Component: cytosol; nucleoplasm; nucleus Molecular Function:ISG15 activating enzyme activity; protein binding; ubiquitin activating enzyme activity; ubiquitin-protein ligase activity Biological Process: bypass DNA synthesis; ISG15-protein conjugation; modification-dependent protein catabolic process; negative regulation of interferon type I production; protein modification process |
NCBI Summary: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008] |
UniProt Code: | P41226 |
NCBI GenInfo Identifier: | 215273977 |
NCBI Gene ID: | 7318 |
NCBI Accession: | P41226.2 |
UniProt Secondary Accession: | P41226,Q9BRB2, |
UniProt Related Accession: | P41226 |
Molecular Weight: | 111,694 Da |
NCBI Full Name: | Ubiquitin-like modifier-activating enzyme 7 |
NCBI Synonym Full Names: | ubiquitin like modifier activating enzyme 7 |
NCBI Official Symbol: | UBA7 |
NCBI Official Synonym Symbols: | D8; UBE2; UBA1B; UBE1L |
NCBI Protein Information: | ubiquitin-like modifier-activating enzyme 7 |
UniProt Protein Name: | Ubiquitin-like modifier-activating enzyme 7 |
UniProt Synonym Protein Names: | D8; Ubiquitin-activating enzyme E1 homolog |
Protein Family: | Ubiquitin-like modifier-activating enzyme |
UniProt Gene Name: | UBA7 |
UniProt Entry Name: | UBA7_HUMAN |