U2AF1 Antibody (PACO43020)
- SKU:
- PACO43020
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | U2AF1 Antibody (PACO43020) |
抗体コード: | PACO43020 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Splicing factor U2AF 35 kDa subunit protein (1-240AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO43020 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human lung cancer using PACO43020 at dilution of 1:100. |
バックグラウンド: | Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. |
シノニム: | Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit), U2AF1, U2AF35 U2AFBP |
UniProt Protein Function: | U2AF1: Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. Belongs to the splicing factor SR family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Spliceosome; RNA splicing; RNA-binding; RNA processing Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: nucleoplasm; spliceosome; Cajal body; nuclear speck Molecular Function:RS domain binding; protein binding; metal ion binding; nucleotide binding Biological Process: transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; mRNA export from nucleus; RNA splicing; gene expression; mRNA 3'-end processing; mRNA processing; termination of RNA polymerase II transcription |
NCBI Summary: | This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q01081 |
NCBI GenInfo Identifier: | 267187 |
NCBI Gene ID: | 7307 |
NCBI Accession: | Q01081.3 |
UniProt Secondary Accession: | Q01081,Q701P4, Q71RF1, |
UniProt Related Accession: | Q01081 |
Molecular Weight: | 240 |
NCBI Full Name: | Splicing factor U2AF 35 kDa subunit |
NCBI Synonym Full Names: | U2 small nuclear RNA auxiliary factor 1 |
NCBI Official Symbol: | U2AF1 |
NCBI Official Synonym Symbols: | RN; FP793; U2AF35; U2AFBP; RNU2AF1 |
NCBI Protein Information: | splicing factor U2AF 35 kDa subunit; splicing factor U2AF 35kDa subunit; U2 small nuclear RNA auxillary factor 1; U2 snRNP auxiliary factor small subunit; U2(RNU2) small nuclear RNA auxiliary factor binding protein; U2 small nuclear ribonucleoprotein auxillary factor, 35-KD subunit |
UniProt Protein Name: | Splicing factor U2AF 35 kDa subunit |
UniProt Synonym Protein Names: | U2 auxiliary factor 35 kDa subunit; U2 small nuclear RNA auxiliary factor 1; U2 snRNP auxiliary factor small subunit |
Protein Family: | Splicing factor |
UniProt Gene Name: | U2AF1 |
UniProt Entry Name: | U2AF1_HUMAN |