TYK2 Antibody (PACO21259)
- SKU:
- PACO21259
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | TYK2 Antibody (PACO21259) |
抗体コード: | PACO21259 |
サイズ: | 100ul(100ug) |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Recombinant protein of human TYK2 |
憲法: | Liquid |
ストレージバッファ: | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts of Raji cell lines, using TYK2 antibody. |
バックグラウンド: | Tyk2, a member of the Jak family of protein tyrosine kinases, associates with and is activated by receptors for many cytokines including IL-13, the IL-6 family, IL-10, and interferon-α and beta. Following ligand binding, Tyk2 is activated by phosphorylation on Tyr1054 and/or Tyr1055. Tyk2 is required for the tyrosine phosphorylation of Stat3 in the IFN-β signaling cascade. |
シノニム: | TYK2; JTK1 |
UniProt Protein Function: | Tyk2: a non-receptor tyrosine-protein kinase of the JakA family. Activated in signaling from the IL-2, gp130 and IFN families of receptors. Phosphorylates the interferon-alpha/beta receptor alpha chain. |
UniProt Protein Details: | Protein type:Protein kinase, TK; EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; JakA family Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; cytoplasm; nucleus; cytosol Molecular Function:protein binding; growth hormone receptor binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; type 1 angiotensin receptor binding; ATP binding Biological Process: cell migration; cytokine and chemokine mediated signaling pathway; innate immune response; cell differentiation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation Disease: Immunodeficiency 35 |
NCBI Summary: | This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008] |
UniProt Code: | P29597 |
NCBI GenInfo Identifier: | 56405328 |
NCBI Gene ID: | 7297 |
NCBI Accession: | P29597.3 |
UniProt Secondary Accession: | P29597,Q6QB10, Q96CH0, |
UniProt Related Accession: | P29597 |
Molecular Weight: | 1187 |
NCBI Full Name: | Non-receptor tyrosine-protein kinase TYK2 |
NCBI Synonym Full Names: | tyrosine kinase 2 |
NCBI Official Symbol: | TYK2 |
NCBI Official Synonym Symbols: | JTK1; IMD35 |
NCBI Protein Information: | non-receptor tyrosine-protein kinase TYK2 |
UniProt Protein Name: | Non-receptor tyrosine-protein kinase TYK2 |
Protein Family: | Non-receptor tyrosine-protein kinase |
UniProt Gene Name: | TYK2 |
UniProt Entry Name: | TYK2_HUMAN |
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